tetano
Editor, Senior Moderator
Front Immunol
. 2025 May 16:16:1593577.
doi: 10.3389/fimmu.2025.1593577. eCollection 2025. Correlation between severe acute respiratory syndrome coronavirus 2 infection and serum anti-neutrophil cytoplasmic antibody formation
Hao Huang[SUP] #[/SUP][SUP] 1 [/SUP], Yu-Jie Zang[SUP] #[/SUP][SUP] 1 [/SUP], Zheng-Guo Li[SUP] 1 [/SUP], Qian Li[SUP] 1 [/SUP], Chun-Yan Ma[SUP] 1 [/SUP], Hai-Yuan Zhao[SUP] 1 [/SUP], Hang Li[SUP] 1 [/SUP]
Affiliations
Objective: To investigate the impact of SARS-CoV-2 infection on the formation of antineutrophil cytoplasmic antibodies (ANCA).
Methods: Serum samples from 154 patients infected with SARS-CoV-2 were collected and tested for ANCA and antinuclear antibodies (ANA) using indirect immunofluorescence assay (IFA). Enzyme-linked immunosorbent assay (ELISA) was used to confirm the target antigens in ANCA fluorescence-positive samples. Eighty-seven healthy individuals were selected as the control group. Statistical analysis was performed using SPSS 26.0 software, with P < 0.05 considered statistically significant.
Results: The ANCA fluorescence positivity rate in the control group (1.1%) was not significantly different from that in COVID-19 positive patients (2.5%) (χ² = 0.574, P > 0.05). Among COVID-19 positive patients, 4 cases (2.5%) were ANCA fluorescence positive, while 10 cases (6.4%) were ANA positive. The difference between these two rates was not statistically significant (χ² = 2.694, P > 0.05).
Conclusion: The Omicron variant of SARS-CoV-2 has minimal association with the formation of serum ANCA.
Keywords: anti-neutrophil cytoplasmic antibody; antinuclear antibody; indirect immunofluorescence assay; infection; severe acute respiratory syndrome coronavirus.
. 2025 May 16:16:1593577.
doi: 10.3389/fimmu.2025.1593577. eCollection 2025. Correlation between severe acute respiratory syndrome coronavirus 2 infection and serum anti-neutrophil cytoplasmic antibody formation
Hao Huang[SUP] #[/SUP][SUP] 1 [/SUP], Yu-Jie Zang[SUP] #[/SUP][SUP] 1 [/SUP], Zheng-Guo Li[SUP] 1 [/SUP], Qian Li[SUP] 1 [/SUP], Chun-Yan Ma[SUP] 1 [/SUP], Hai-Yuan Zhao[SUP] 1 [/SUP], Hang Li[SUP] 1 [/SUP]
Affiliations
- PMID: 40453087
- PMCID: PMC12122749
- DOI: 10.3389/fimmu.2025.1593577
Objective: To investigate the impact of SARS-CoV-2 infection on the formation of antineutrophil cytoplasmic antibodies (ANCA).
Methods: Serum samples from 154 patients infected with SARS-CoV-2 were collected and tested for ANCA and antinuclear antibodies (ANA) using indirect immunofluorescence assay (IFA). Enzyme-linked immunosorbent assay (ELISA) was used to confirm the target antigens in ANCA fluorescence-positive samples. Eighty-seven healthy individuals were selected as the control group. Statistical analysis was performed using SPSS 26.0 software, with P < 0.05 considered statistically significant.
Results: The ANCA fluorescence positivity rate in the control group (1.1%) was not significantly different from that in COVID-19 positive patients (2.5%) (χ² = 0.574, P > 0.05). Among COVID-19 positive patients, 4 cases (2.5%) were ANCA fluorescence positive, while 10 cases (6.4%) were ANA positive. The difference between these two rates was not statistically significant (χ² = 2.694, P > 0.05).
Conclusion: The Omicron variant of SARS-CoV-2 has minimal association with the formation of serum ANCA.
Keywords: anti-neutrophil cytoplasmic antibody; antinuclear antibody; indirect immunofluorescence assay; infection; severe acute respiratory syndrome coronavirus.