tetano
Editor, Senior Moderator
Front Immunol
. 2023 Mar 20;14:1070077.
doi: 10.3389/fimmu.2023.1070077. eCollection 2023.
Architecture of the SARS-CoV-2-specific T cell repertoire
Ksenia V Zornikova[SUP] 1 [/SUP], Saveliy A Sheetikov[SUP] 1 2 [/SUP], Alexander Yu Rusinov[SUP] 1 2 [/SUP], Rustam N Iskhakov[SUP] 1 2 [/SUP], Apollinariya V Bogolyubova[SUP] 1 [/SUP]
Affiliations
Abstract
The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens-in particular, common cold coronaviruses-impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants.
Keywords: SARS-CoV-2; T cell immune response; T cell receptors; T cell repertoire; T cell repertoire dynamic.
. 2023 Mar 20;14:1070077.
doi: 10.3389/fimmu.2023.1070077. eCollection 2023.
Architecture of the SARS-CoV-2-specific T cell repertoire
Ksenia V Zornikova[SUP] 1 [/SUP], Saveliy A Sheetikov[SUP] 1 2 [/SUP], Alexander Yu Rusinov[SUP] 1 2 [/SUP], Rustam N Iskhakov[SUP] 1 2 [/SUP], Apollinariya V Bogolyubova[SUP] 1 [/SUP]
Affiliations
- PMID: 37020560
- PMCID: PMC10067759
- DOI: 10.3389/fimmu.2023.1070077
Abstract
The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens-in particular, common cold coronaviruses-impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants.
Keywords: SARS-CoV-2; T cell immune response; T cell receptors; T cell repertoire; T cell repertoire dynamic.