tetano
Editor, Senior Moderator
Front Endocrinol (Lausanne)
. 2020 Jul 14;11:478.
doi: 10.3389/fendo.2020.00478. eCollection 2020.
Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan
Zeming Liu[SUP] 1 [/SUP], Jinpeng Li[SUP] 2 [/SUP], Jianglong Huang[SUP] 1 [/SUP], Liang Guo[SUP] 1 [/SUP], Rongfen Gao[SUP] 3 [/SUP], Kuan Luo[SUP] 4 [/SUP], Guang Zeng[SUP] 5 [/SUP], Tingbao Zhang[SUP] 6 [/SUP], Meilin Yi[SUP] 7 [/SUP], Yihui Huang[SUP] 1 [/SUP], Jincao Chen[SUP] 6 [/SUP], Yibin Yang[SUP] 8 [/SUP], Xiaohui Wu[SUP] 6 [/SUP]
Affiliations
Abstract
Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.
Keywords: Coronavirus disease 2019 (COVID-19); clinical courses; comorbidity; diabetes mellitus; prognosis.
. 2020 Jul 14;11:478.
doi: 10.3389/fendo.2020.00478. eCollection 2020.
Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan
Zeming Liu[SUP] 1 [/SUP], Jinpeng Li[SUP] 2 [/SUP], Jianglong Huang[SUP] 1 [/SUP], Liang Guo[SUP] 1 [/SUP], Rongfen Gao[SUP] 3 [/SUP], Kuan Luo[SUP] 4 [/SUP], Guang Zeng[SUP] 5 [/SUP], Tingbao Zhang[SUP] 6 [/SUP], Meilin Yi[SUP] 7 [/SUP], Yihui Huang[SUP] 1 [/SUP], Jincao Chen[SUP] 6 [/SUP], Yibin Yang[SUP] 8 [/SUP], Xiaohui Wu[SUP] 6 [/SUP]
Affiliations
- PMID: 32760350
- PMCID: PMC7371935
- DOI: 10.3389/fendo.2020.00478
Abstract
Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.
Keywords: Coronavirus disease 2019 (COVID-19); clinical courses; comorbidity; diabetes mellitus; prognosis.