tetano
Editor, Senior Moderator
Front Cell Dev Biol
. 2021 Apr 27;9:578825.
doi: 10.3389/fcell.2021.578825. eCollection 2021.
The Mechanisms and Animal Models of SARS-CoV-2 Infection
Wenrui Jia[SUP] 1 [/SUP], Juan Wang[SUP] 1 [/SUP], Bao Sun[SUP] 2 [/SUP], Jiecan Zhou[SUP] 3 [/SUP], Yamin Shi[SUP] 1 [/SUP], Zheng Zhou[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has aroused great public health concern worldwide. Currently, COVID-19 epidemic is spreading in many countries and regions around the world. However, the study of SARS-CoV-2 is still in its infancy, and there is no specific therapeutics. Here, we summarize the genomic characteristics of SARS-CoV-2. In addition, we focus on the mechanisms of SARS-CoV-2 infection, including the roles of angiotensin converting enzyme II (ACE2) in cell entry, COVID-19 susceptibility and COVID-19 symptoms, as well as immunopathology such as antibody responses, lymphocyte dysregulation, and cytokine storm. Finally, we introduce the research progress of animal models of COVID-19, aiming at a better understanding of the pathogenesis of COVID-19 and providing new ideas for the treatment of this contagious disease.
Keywords: angiotensin converting enzyme II; animal models; immunopathology; pathogenesis; severe acute respiratory syndrome coronavirus 2.
. 2021 Apr 27;9:578825.
doi: 10.3389/fcell.2021.578825. eCollection 2021.
The Mechanisms and Animal Models of SARS-CoV-2 Infection
Wenrui Jia[SUP] 1 [/SUP], Juan Wang[SUP] 1 [/SUP], Bao Sun[SUP] 2 [/SUP], Jiecan Zhou[SUP] 3 [/SUP], Yamin Shi[SUP] 1 [/SUP], Zheng Zhou[SUP] 1 [/SUP]
Affiliations
- PMID: 33987176
- PMCID: PMC8111004
- DOI: 10.3389/fcell.2021.578825
Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has aroused great public health concern worldwide. Currently, COVID-19 epidemic is spreading in many countries and regions around the world. However, the study of SARS-CoV-2 is still in its infancy, and there is no specific therapeutics. Here, we summarize the genomic characteristics of SARS-CoV-2. In addition, we focus on the mechanisms of SARS-CoV-2 infection, including the roles of angiotensin converting enzyme II (ACE2) in cell entry, COVID-19 susceptibility and COVID-19 symptoms, as well as immunopathology such as antibody responses, lymphocyte dysregulation, and cytokine storm. Finally, we introduce the research progress of animal models of COVID-19, aiming at a better understanding of the pathogenesis of COVID-19 and providing new ideas for the treatment of this contagious disease.
Keywords: angiotensin converting enzyme II; animal models; immunopathology; pathogenesis; severe acute respiratory syndrome coronavirus 2.