tetano
Editor, Senior Moderator
Front Cardiovasc Med
. 2022 Jan 21;8:795750.
doi: 10.3389/fcvm.2021.795750. eCollection 2021.
The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis
Ziqi Tan[SUP] 1 [/SUP], Shan Huang[SUP] 2 [/SUP], Kaibo Mei[SUP] 3 [/SUP], Menglu Liu[SUP] 4 [/SUP], Jianyong Ma[SUP] 5 [/SUP], Yuan Jiang[SUP] 6 [/SUP], Wengen Zhu[SUP] 7 [/SUP], Peng Yu[SUP] 1 [/SUP], Xiao Liu[SUP] 8 [/SUP]
Affiliations
Abstract
Background: Arrhythmia is a very common complication of coronavirus disease 2019 (COVID-19); however, the prevalence of ventricular arrhythmia and associated outcomes are not well-explored. Here, we conducted a systematic review and meta-analysis to determine the prevalence and associated death of ventricular arrhythmia and sudden cardiac death (SCD) in patients with COVID-19.
Methods: Databases of PubMed, Cochrane Library, Embase, and MdeRxiv were searched. Studies that could calculate the prevalence of ventricular arrhythmia/SCD during hospital admission or associated death in patients with COVID-19 were included. The study was registered with the PROSPERO (CRD42021271328).
Results: A total of 21 studies with 13,790 patients were included. The pooled prevalence of ventricular arrhythmia was 5% (95% CI: 4-6%), with a relatively high-SCD prevalence (1.8% in hospitalized COVID-19 and 10% in deceased cases of COVID-19). Subgroup analysis showed that ventricular arrhythmia was more common in patients with elevated cardiac troponin T [ES (effect size): 10%, 95% CI: -0.2 to 22%] and in European (ES: 20%, 95% CI: 11-29%) populations. Besides, ventricular arrhythmia was independently associated with an increased risk of death in patients with COVID-19 [odds ratio (OR) = 2.83; 95% CI: 1.78-4.51].
Conclusion: Ventricular arrhythmia and SCD resulted as a common occurrence with a high prevalence in patients with COVID-19 admitted to the hospital. Furthermore, ventricular arrhythmia significantly contributed to an increased risk of death in hospitalized patients with COVID-19. Clinicians might be vigilant of ventricular arrhythmias for patients with COVID-19, especially for severe cases.
Systematic review registration: www.york.ac.uk/inst/crd, identifier: CRD42021271328.
Keywords: arrhythmia; coronavirus disease 2019; death; prevalence; prognosis; ventricular arrhythmia.
. 2022 Jan 21;8:795750.
doi: 10.3389/fcvm.2021.795750. eCollection 2021.
The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis
Ziqi Tan[SUP] 1 [/SUP], Shan Huang[SUP] 2 [/SUP], Kaibo Mei[SUP] 3 [/SUP], Menglu Liu[SUP] 4 [/SUP], Jianyong Ma[SUP] 5 [/SUP], Yuan Jiang[SUP] 6 [/SUP], Wengen Zhu[SUP] 7 [/SUP], Peng Yu[SUP] 1 [/SUP], Xiao Liu[SUP] 8 [/SUP]
Affiliations
- PMID: 35127861
- PMCID: PMC8814312
- DOI: 10.3389/fcvm.2021.795750
Abstract
Background: Arrhythmia is a very common complication of coronavirus disease 2019 (COVID-19); however, the prevalence of ventricular arrhythmia and associated outcomes are not well-explored. Here, we conducted a systematic review and meta-analysis to determine the prevalence and associated death of ventricular arrhythmia and sudden cardiac death (SCD) in patients with COVID-19.
Methods: Databases of PubMed, Cochrane Library, Embase, and MdeRxiv were searched. Studies that could calculate the prevalence of ventricular arrhythmia/SCD during hospital admission or associated death in patients with COVID-19 were included. The study was registered with the PROSPERO (CRD42021271328).
Results: A total of 21 studies with 13,790 patients were included. The pooled prevalence of ventricular arrhythmia was 5% (95% CI: 4-6%), with a relatively high-SCD prevalence (1.8% in hospitalized COVID-19 and 10% in deceased cases of COVID-19). Subgroup analysis showed that ventricular arrhythmia was more common in patients with elevated cardiac troponin T [ES (effect size): 10%, 95% CI: -0.2 to 22%] and in European (ES: 20%, 95% CI: 11-29%) populations. Besides, ventricular arrhythmia was independently associated with an increased risk of death in patients with COVID-19 [odds ratio (OR) = 2.83; 95% CI: 1.78-4.51].
Conclusion: Ventricular arrhythmia and SCD resulted as a common occurrence with a high prevalence in patients with COVID-19 admitted to the hospital. Furthermore, ventricular arrhythmia significantly contributed to an increased risk of death in hospitalized patients with COVID-19. Clinicians might be vigilant of ventricular arrhythmias for patients with COVID-19, especially for severe cases.
Systematic review registration: www.york.ac.uk/inst/crd, identifier: CRD42021271328.
Keywords: arrhythmia; coronavirus disease 2019; death; prevalence; prognosis; ventricular arrhythmia.