Mary Wilson
Well-known member
ERIC TOPOL
7/19/2023
Today in Nature a groundbreaking and compelling report on the genomics of why some people do not manifest symptoms of Covid. And last week 2 papers (here and here) on the genetics of Long Covid. This represents genetic probes for the extreme of the clinical spectrum—from not exhibiting symptoms of SARS-CoV-2 infection to developing a debilitating, chronic condition. In this edition of Ground Truths, I’ll review the 3 new studies and contextualize their importance.
The Genomics of People Without Symptoms of Covid
Since the pandemic began, asymptomatic Covid has been a particular interest of mine, given its pivotal role in spreading infections and the likelihood that host genetics protect some individuals from ever getting sick. My colleague, Danny Oran, and I wrote extensively on this topic, with review papers in Annals of Internal Medicine, with an overall estimate rate of about 30%. We’ve all wondered why some people, even after close and protracted exposure to others with significant Covid illness, do not ever develop symptoms.
In order to identify the genomic variants that may play a role in these clinical phenotypes, a genome-wide association (GWAS) study is performed. ...
https://erictopol.substack.com/p/from-asymptomatic-covid-to-long-covid
7/19/2023
Today in Nature a groundbreaking and compelling report on the genomics of why some people do not manifest symptoms of Covid. And last week 2 papers (here and here) on the genetics of Long Covid. This represents genetic probes for the extreme of the clinical spectrum—from not exhibiting symptoms of SARS-CoV-2 infection to developing a debilitating, chronic condition. In this edition of Ground Truths, I’ll review the 3 new studies and contextualize their importance.
The Genomics of People Without Symptoms of Covid
Since the pandemic began, asymptomatic Covid has been a particular interest of mine, given its pivotal role in spreading infections and the likelihood that host genetics protect some individuals from ever getting sick. My colleague, Danny Oran, and I wrote extensively on this topic, with review papers in Annals of Internal Medicine, with an overall estimate rate of about 30%. We’ve all wondered why some people, even after close and protracted exposure to others with significant Covid illness, do not ever develop symptoms.
In order to identify the genomic variants that may play a role in these clinical phenotypes, a genome-wide association (GWAS) study is performed. ...
https://erictopol.substack.com/p/from-asymptomatic-covid-to-long-covid