tetano
Editor, Senior Moderator
J Infect Dis. 2014 Jun 6. pii: jiu327. [Epub ahead of print]
Frequency of Acute Respiratory Illnesses and Circulation of Respiratory Viruses in Households with Children over Three Surveillance Seasons.
Monto AS1, Malosh RE1, Petrie JG1, Thompson MG2, Ohmit SE1.
Author information
Abstract
BACKGROUND:
The household has traditionally been the site for studying acute respiratory illnesses (ARI). Most studies were conducted many years ago and more broadly sensitive laboratory methods to determine ARI etiology are now available.
METHODS:
We recruited and followed households with children over three annual surveillance periods and collected respiratory specimens from subjects with reported ARI. Virus etiology was determined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay.
RESULTS:
Individuals in larger households (>4 members) and those in households with children age <5 years had significantly higher ARI frequencies than others. ARI frequency generally declined with increasing age. Virus etiology was most likely to be determined in young children, who were also most likely to have virus co-infection. Overall, 16% of ARIs with one virus identified had one or more co-infecting viruses. ARIs caused by rhinoviruses and coronaviruses were most frequently identified in all age categories. ARIs caused by influenza and adenovirus were less frequently identified, but most likely to require medical attention.
CONCLUSIONS:
Longitudinal studies in families remain a valuable way to study respiratory infections. RT-PCR has increased the sensitivity of virus detection, including co-infecting viruses, and expanded our ability to detect viruses now known to cause ARI.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24907381
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24907381
Frequency of Acute Respiratory Illnesses and Circulation of Respiratory Viruses in Households with Children over Three Surveillance Seasons.
Monto AS1, Malosh RE1, Petrie JG1, Thompson MG2, Ohmit SE1.
Author information
Abstract
BACKGROUND:
The household has traditionally been the site for studying acute respiratory illnesses (ARI). Most studies were conducted many years ago and more broadly sensitive laboratory methods to determine ARI etiology are now available.
METHODS:
We recruited and followed households with children over three annual surveillance periods and collected respiratory specimens from subjects with reported ARI. Virus etiology was determined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay.
RESULTS:
Individuals in larger households (>4 members) and those in households with children age <5 years had significantly higher ARI frequencies than others. ARI frequency generally declined with increasing age. Virus etiology was most likely to be determined in young children, who were also most likely to have virus co-infection. Overall, 16% of ARIs with one virus identified had one or more co-infecting viruses. ARIs caused by rhinoviruses and coronaviruses were most frequently identified in all age categories. ARIs caused by influenza and adenovirus were less frequently identified, but most likely to require medical attention.
CONCLUSIONS:
Longitudinal studies in families remain a valuable way to study respiratory infections. RT-PCR has increased the sensitivity of virus detection, including co-infecting viruses, and expanded our ability to detect viruses now known to cause ARI.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24907381
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24907381