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Flu has long incubation period, WHO says

Jeremy

Well-known member
http://www.calgaryherald.com/Health/long+incubation+period+says/1561558/story.html

OTTAWA ? Human swine flu appears to have a longer than normal incubation period, causes diarrhea in about half of those it infects and can lead to severe pneumonia and deaths in young, healthy people, the World Health Organization said Monday.


But what is still not known is how often H1N1 influenza A leads to severe disease.


"I think that right now we do know that some of the people who have died have been young and healthy. But we also know that some of the people who have died have also had other illnesses going along," Dr. Keiji Fukuda, the WHO's temporary assistant director-general for Health Security and the Environment, told reporters.


Three new cases of swine flu were reported in Canada Monday, two in Prince Edward Island and one in New Brunswick, bringing Canada's total to 104. WHO said the number of global cases stands at 1,025 from 20 countries, including 26 deaths.


The New Brunswick case, the province's second, involved a woman in her 40s from the Fredericton area who has already recovered. Both cases in PEI were mild, according to the PEI Department of Health. Neither case was hospitalized.


The new H1N1 swine flu has now infected 286 people in 36 states, the U.S. Centers for Disease Control and Prevention reported on Monday.

CDC officials have said they expect to see more cases as the flu spreads across the country. Most cases remain mild but a toddler, who was from Mexico, died in Texas last week. In Mexico officials say they hope cases will continue to decline.


Globally, the largest number of cases have been reported in North America, from Mexico, the U.S. and Canada, though the virus appears to be on the move, with infections occurring in Asia, Europe and Latin America.


But Fukuda says, "we do not have any evidence that the virus has taken hold and led to community-level transmission in any other countries right now."


The World Health Organization is one step away from calling the swine flu outbreaks a pandemic. Last week it raised its alert level to phase five on a six-phase scale. The change was meant as a signal that a pandemic is likely imminent and that countries should activate their pandemic preparedness plans.


"We are not certain when we will go to phase 6," Fukuda said. "There's not a timetable. There's no timetable for how viruses like this spread out."

But even then, going to phase 6 doesn't say anything about the severity of the disease.


"Phase 6 means that we are seeing continued spread of the virus to countries outside of one region," Fukuda said. "If you are seeing community outbreaks occur in multiple regions of the world it really tells us that the virus has established itself and that we can expect to see disease in most countries in the world."


That's different than the severity of the pandemic.


"Severity has to do with when people get infected, how often are they going to develop really severe disease? Will we see younger people develop serious disease more often than usual? Will there be anything unusual about pregnant women? Will there be anything unusual about children? These are the kinds of things we would be looking at in order to determine severity."


Twenty five Universite de Montreal students, in China to study Mandarin, and their teacher have been placed under quarantine in northern China for seven days as a precaution against swine flu.


Provincial health authorities stopped the group yesterday upon their arrival in Changchun airport in the province of Jilin. They had their temperatures taken at the airport and then bused to a

university dormitory. None of the students are reported to have fever.

Twenty countries worldwide had banned imports of pork as of Monday in response to the discovery of the new H1N1 flu strain in a herd of pigs on a central Alberta hog farm.


While the new H1N1 strain is not food-borne, fears that it may spread through animal products have prompted restrictions on live pigs, pork, cattle, poultry, livestock, feed and animal semen from countries with reported infections, according to World Health Organization documents obtained by Reuters on Monday.


"We are very clear that pork and pork products when they're handled right and when they're cooked properly do not pose a risk of infection to people," Fukuda says. "Here, we are dealing with a situation where the people who are getting infected are not getting infected from pigs.


"However, we also want to be careful and make sure there is no risk and so this is something we would continue to look at whether pigs may pose a risk to some people. But this is really not how people are getting infected and this is very important to understand. The pigs are not the danger to people right now. The danger is from people transmitting the infection to other people and this is what we hope to control as much as possible."


Health Canada is warning consumers to be wary against counterfeit and unapproved products, from dietary supplements and flu "detoxes" to bogus vaccines, that have flooded the Internet claiming to help diagnose, prevent or cure human swine flu.


The drugs could contain active ingredients not listed on the label and could cause serious side effects, the health agency says.


Some claim to be "generic" versions of the flu drugs, Tamiflu or Relenza ? drugs that should only be purchased with a prescription from a doctor and used only if the person is sick with moderate to severe flu or is at high risk of flu-related complications, officials say.


Federal officials believe the infected pigs on the central Alberta hog farm ? the first known case of humans transferring the new strain into animals ? contracted the virus from a Canadian worker who returned from Mexico on April 12 and arrived on the farm two days later, showing flu symptoms shortly thereafter. One other person on the farm has had mild symptoms. Officials are awaiting test results.


Both the worker and the approximately 220 infected pigs are recovering, but the animals have been quarantined, say officials.


The countries that have imposed bans include Russia, China, Switzerland, Croatia, Indonesia, Thailand and Ecuador.


Most affect products from Mexico and the United States and some block imports from Canada, New Zealand, Spain, France, Israel, Costa Rica, El Salvador, Colombia, Cuba, Nicaragua, Panama, Honduras, Guatemala and the Dominican Republic.


Global trade in pork meat is worth about $26 billion a year.


The three countries most affected by the bans announced to date ? Mexico, the United States and Canada ? are among the world's top pork exporters, along with the European Union, Brazil, Chile, China and Hong Kong.


WHO chief Margaret Chan said there was "no indication that we are facing a situation similar to that in 1918," when a flu pandemic killed tens of millions.


The WHO continues to say consumption of pork is safe and said there are no plans to put down any of the infected animals.


WHO Dr. Peter Ben Embarek said there are no recommendations to cull any pigs.


Canadian officials also urged consumers not be concerned about the virus entering the food chain.


Dr. Brian Evans, executive vice-president of the Canadian Food Inspection Agency and Canada's chief veterinary officer, stressed there was no food-safety concern and said consumption of pork is not considered a route of transmission to humans.


Dr. Ho Pak-leung, associate professor at University of Hong Kong's microbiology department, is concerned the transmission of the flu virus from humans to pigs indicates a new medium of transmission for the virus.

Ho says he believes this H1N1 flu virus will become increasingly difficult to control if more pigs are infected by this human swine flu virus. There's also a high risk the virus can mutate inside infected pigs, creating new strains of the animal flu, he said.


The transfer of a flu virus from humans to pigs is not unheard of, he says, pointing out the influenza viruses of the Hong Kong flu pandemic also transferred from humans to pigs, and vice versa. That pandemic killed nearly one million people in 1968 and 1969.


"Once the human virus is transmitted to pigs, anyone that comes in contact with infected pigs will have chance of contracting this (H1N1) virus," he says.


There's also a high risk the virus can mutate inside infected pigs, Ho adds, creating new strains of the animal flu.


"A single pig can be infected with different influenza viruses," he says. "So, there's a chance that the genes of the influenza virus may 'shuffle' inside the pigs . . . forming a new virus."


However, Ho stresses that pork products are safe to eat, since the H1N1 disease cannot be contracted from eating cooked pork, as the flu virus is killed at temperatures of 70 C.


Meanwhile, China says it is not targeting Mexican citizens in its stepped-up bid to keep H1N1 flu off the Mainland, but a skeptical Mexican government dispatched an airplane Monday to take its sequestered nationals home, anyway.


There are now several reports that Mexicans, with no exposure to the flu or flu victims, are being quarantined in China on the basis of their passports.


The Mexican ambassador in Beijing, Jorge Guajardo, told journalists: "In many cases we have gotten reports that they were being quarantined for the sole fact that they had a Mexican passport, whether or not they came from Mexico, whether or not they had been in Mexico, whether or not they had been in contact with someone else from Mexico."


The Chinese Foreign Ministry was quick to respond.


"The measures concerned are not targeted at Mexican citizens and there is no discrimination," Foreign Ministry spokesman Ma Zhaoxu said in a statement. "This is purely a medical quarantine issue," Ma said. "Those measures were not targeting Mexican citizens. There is no discrimination. This was purely a medical quarantine issue."


Some 70 Mexican citizens are now quarantined across Mainland China, according to Mexican embassy officials. Many of them had no connection with the AeroMexico airline passenger flight that transited through Shanghai to Hong Kong last Thursday. Once in Hong Kong, one passenger from the flight tested positive for the flu virus and now all passengers and crew are under quarantine in Hong Kong or on the Mainland.


But the Mexican embassy, backed up by Internet reports and news reports, claim Chinese officials have been isolating Mexican citizens on other flights, as well, and putting them in quarantine, even when they have no immediate history of exposure in Mexico or to the flu virus.

China was quick to suspend all flights to Mexico but over the weekend announced it would send a special flight Monday to rescue any of its citizens stranded in the holiday hot spot. On Monday, however, it said the flight was cancelled because "the airline was unable to reach a landing agreement with Mexican airports."


It smacked of an escalating diplomatic spat, but late in the day tempers appeared to cool and the two sides said arrangements were being made to repatriate nationals from both countries.
 
Re: Flu has long incubation period, WHO says

This text could explain some of the things stated above:

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From WHO website: http://www.who.int



WHO ad hoc scientific teleconference on the current influenza A(H1N1) situation

29 April 2009


On 29 April 2009 WHO hosted a teleconference that included more than one hundred participants from all of the WHO Regions. The objectives of the teleconference were to gain a better understanding of the situation in affected countries; to update and share preliminary epidemiological, clinical and virological information and to identify key knowledge gaps needed to address immediate public health questions. The format of the teleconference was a series of situation updates followed by a moderated question and answer session. Listeners were given the opportunity to submit questions electronically. Information was provided by the following agencies and organizations: the Direcci?n General de Epidemiolog?a (DGEPI) and the Instituto de Diagnostico y Referencia Epidmiologicos (INDRE); the US Centers for Disease Control and Prevention (CDC); the New York City Department of Health and Mental Hygiene; the California Department of Public Health and the Public Health Agency of Canada.

Each of the following situation updates includes a brief history of how cases were first identified, ongoing surveillance activities and available clinical, epidemiological and virological information. The information should be considered preliminary as the situation is rapidly evolving and investigations are ongoing.


Mexico

Editorial note: Since the teleconference, a detailed and updated report of the initial and ongoing investigation of influenza A(H1N1) has been published at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0430a2.htm.

Initial detection
Routine influenza surveillance first detected an increase in the number of cases and outbreaks of influenza-like illness (ILI) in late January/early February 2009. The reports were considered to be typical of seasonal influenza and a mix of seasonal influenza A and influenza B viruses were identified. Mexican health officials believe that the outbreak of the newly emerged influenza A(H1N1) virus likely began in mid-March. Surveillance
began to identify cases of ILI at a time when seasonal outbreaks typically are declining.

By mid-April, cases and clusters of severe pneumonia, primarily in previously healthy young adults, were occurring.

On 14 April clinicians treating a hospitalised patient with atypical severe pneumonia in Oxaca State grew concerned about the unusual nature of the
case.

The patient was a previously healthy young adult (age in late 30s) who recently had been diagnosed with uncomplicated diabetes. The patient died following a rapidly progressive course. Clinicians considered severe acute respiratory syndrome (SARS) as a possible cause but the patient tested negative for SARS. This case prompted enhanced surveillance throughout Mexico.

Post-mortem testing done after the new influenza A(H1N1) virus had been identified in Mexico determined that the patient had been infected with the newly emerged influenza A(H1N1) virus.

Specimens were sent to the Public Health Agency of Canada's National Microbiology Laboratory on 22 April.

On 23 April influenza A(H1N1) was identified in 17 of 18 samples tested.

Surveillance information
On 17 April, Mexican health officials began enhanced surveillance for severe respiratory disease. Surveillance was expanded on 23 April to include suspect cases (i.e. severe respiratory disease); probable cases (i.e. a suspect case with laboratory evidence of influenza A); and confirmed cases (i.e. a probable case with laboratory evidence of the newly emerged influenza A(H1N1) virus).

For the period 17-27 April, 26 confirmed cases (7 deaths), 286 probable cases and 1551 suspect cases (84 deaths) have been reported. Cases are being reported throughout the country with suspect cases in all states. Most of the confirmed cases and deaths have been reported from the Federal District of Mexico; cases have also been confirmed from Mexico State, Veracruz State and Oxaca State.

Most infected persons have been between 20 and 55 years of age; among confirmed cases, age has ranged from 4 and 58 years. The age distribution is similar for fatal cases.

Clinical information
A spectrum of illness ranging from severe respiratory disease to mild illness has been reported.

Among the first 25 confirmed cases, all of whom were hospitalised with severe pneumonia, approximately 90% had cough, fever, malaise and headache. Few data are available at this time regarding secondary bacterial infections.

Typical hospital-acquired pathogens, such as Pseudomonas aeruginosa, have been detected in a few patients who were hospitalized for prolonged periods of time.

In a small community in the State of Veracruz, an outbreak of mild ILI affected about 50% of the population.

Among ill persons who were not found to have the newly emerged influenza A(H1N1), other pathogens that have been isolated include seasonal influenza A and B, parainfluenza (23 samples), respiratory syncytial virus (1 sample) and adenovirus (1 sample).

Epidemiological information
Investigations are underway to assess community and hospital contacts of confirmed cases.

Follow-up of contacts of one fatal case found a clinical attack rate of 20% and 45% among 106 community and 105 hospital contacts, respectively.

None of the contacts for this case patient had severe disease. Clusters of confirmed cases have been found in hospitals but it is uncertain if these
represent hospital- or community-based transmission. A small number of cases have been reported in health care workers. However, it has not been possible to determine the source of their infection. Most of the health care workers had household contacts that developed illness at about the same time. There are no data available at this time to indicate that health care workers are at increased risk.

Case control studies are in progress to assess possible risk factors for infection, outcome and other epidemiological parameters. Further study of the small community in the State of Veracruz that experienced an outbreak of mild ILI also is planned.

Virological information
During the period 15 March - 29 April, 112 specimens were tested from suspect and probable cases and 48 were confirmed as influenza A(H1N1). Sequencing of the first 25 strains has found that all are similar to the viruses isolated from cases in California. Some samples collected 6-7 days after the onset of illness have tested positive by real-time RT-PCR. Only respiratory specimens have been tested.


United States

Editorial note: Detailed reports of the initial investigations of influenza A(H1N1) in California and Texas have been published at:
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0421a1.htm;
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0424a1.htm.

Initial detection
CDC first identified influenza A(H1N1) infections in two children with a febrile respiratory illness in adjacent counties in southern California. Shortly thereafter, four additional cases were reported from California and two from Texas.

Surveillance information
At the time of the teleconference, 64 confirmed cases had been identified from 14 states. The first confirmed death was reported on 29 April in a 23 month old child. Enhanced surveillance for additional cases is ongoing throughout the United Sates.

Clinical information
Initial cases had mild illness. However, more severe manifestations have been found in some recent cases.

A small number of cases have been hospitalised; all of these patients were at increased risk for complications of seasonal influenza (e.g. young infant or person with chronic underlying medical condition).

Most cases have reported upper respiratory tract symptoms, fever and muscle aches; approximately 20% to 25% had gastro-intestinal symptoms such as vomiting or diarrhea.

Epidemiological information
To date widespread transmission has not been observed in the United States. However, it is likely that ongoing human-to-human transmission is occurring in a number of areas such as New York City.

Virological information
Triple reassortant influenza viruses (containing genes from human, North American lineage swine viruses and North American lineage avian influenza A viruses) have circulated among swine in the United States since 1999 and caused sporadic human infections. The majority of the genes in the new H1N1 virus, including the hemagglutinin (HA) gene, are similar to those of previously circulating swine viruses. However, the genes coding for the neuraminidase (NA) and matrix (M) proteins are similar to the swine
influenza viruses circulating in Europe and Asia (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0421a1.htm). All of the gene segments in this new quadruple reassortant virus have been previously found in swine
from the United States, Europe or Asia. However, this combination of swine influenza virus segments has not been detected previously among swine or human isolates. Efforts are underway to develop a vaccine seed strain using reverse genetics techniques. Molecular sequence analysis of the HA gene has found that all isolates to date are nearly identical which will facilitate vaccine development.

New York City
Editorial note: Since the teleconference, a detailed and updated report of the initial and ongoing investigation of influenza A(H1N1) has been published at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0430a1.htm

Initial detection
On 23 April the New York City Department of Health and Mental Hygiene was notified of increased absenteeism among students in a private secondary school in the borough of Queens. Of nearly 2700 enrolled students, approximately 200 students reported an ILI and sore throat. Eight specimens were obtained and confirmed to be influenza A(H1N1) on 26 April. The school was closed on 27 April and remains closed.

Surveillance information
At the time of the teleconference, a total of 44 confirmed cases had been identified. An online survey of students suggests that there are likely hundreds more additional cases of illness among students, teachers and household contacts. Several students reported in the on-line survey that they had travelled to Mexico during the week before 20 April; however,
none of these were among the confirmed cases. A number of reports of ILI have been received from other schools. A second school was closed in New York City on 28 April in response to reports of ILI in 10 to 12 students and some staff members; siblings of the students in this second school attend the school in Queens.

There are many reports of travellers with mild ILI who have not been tested. There is one probable case in a 19 month old Mexican child with no history of travel or other epidemiologic links to cases in the secondary school. Officials believe that there are likely hundreds more unconfirmed and/or undetected cases.

Clinical information
Among the 44 confirmed cases, 80% or more reported each of the following symptoms: c ough, subjective fever, fatigue, headache, chills, sore throat, runny nose, and muscle aches. A few cases have had diarrhea, stomach pain and joint pain. Illness has been mild in all reported cases to date and has resolved spontaneously without treatment in some
instances.

Health officials are contacting 65 hospital intensive care units each day for suspicious cases of severe respiratory disease; none have been found to date.

Epidemiological information
Secondary transmission has been documented from students to household contacts.

Virological information
A small number of non-respiratory specimens (type not specified) are being tested but results are not yet available.

California
Initial detection
Two children with the onset of ILI in late March were identified through routine surveillance along the California-Mexican border. Initial testing determined that they were infected with an unsubtypable influenza A virus that was later determined to be influenza A(H1N1) virus http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0421a1.htm). On
24 April, four additional cases were reported in California (http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0424a1.htm) .

Surveillance information
At the time of the teleconference, a total of 10 confirmed cases had been reported. Surveillance for ILI has been enhanced along the border with Mexico and among sentinel providers; unusual increases in ILI have not been detected. Additional surveillance efforts are focused on patients with ILI in hospitals and out-patient settings; persons in contact with a confirmed case, persons in closed settings such as homeless shelters, schools and prisons, travellers who have returned from an area with confirmed cases and clusters of ILI.

Once a confirmed case has been identified as part of a cluster, further testing of cluster members is not being pursued to preserve resources. If a probable case is identified in a school student, the school has been closed until confirmatory testing results are available.

Clinical information
Most cases have had a mild ILI; only two cases have been hospitalised; one had an autoimmune disorder and the second had two unspecified underlying medical conditions.

Antiviral drugs have not been used to treat any patients to date.

Canada
Initial detection
Suspect cases were first reported on 23 April. On April 26 four cases of influenza A/H1N1 from Nova Scotia and two cases from British Columbia were confirmed. All six cases are the same strain of human swine influenza found in the Unied States and Mexico.

Surveillance information
At the time of the teleconference, 13 laboratory confirmed cases had been identified from four provinces (British Columbia, Ontario, Nova Scotia and Alberta Vancouver).

Epidemiological information
All of the confirmed cases have travel linkages to Mexico with the exception of some cases in the Nova Scotia cluster.

Clinical information
All of the cases to date have had mild illness.

Virological information
The National Microbiology Laboratory is undertaking development work for diagnostic tests and vaccines.

-
-----
 
Re: Flu has long incubation period, WHO says

Investigations are underway to assess community and hospital contacts of confirmed cases.

Follow-up of contacts of one fatal case found a clinical attack rate of 20% and 45% among 106 community and 105 hospital contacts, respectively.

This could be the 39 year old census taker, Maria Cruz Jovita Gutierrez, from Oaxaca. She had illlness onset on April 3, hospitalized on April 8 at Hospital General ?Dr. Aurelio Valdivieso?, and died on April 13, 2009.

Link: http://www.diariodespertar.com.mx/Ag...Sanitaria.html
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