Flu deaths in Middle Tennessee rise to 12

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Source: http://www.tennessean.com/article/20140112/NEWS01/301120108


Flu deaths in Middle Tennessee rise to 12
Jan. 12, 2014 4:54 PM |
Written by
Josh Brown
The Tennessean


The death toll from this season?s flu virus in Middle Tennessee has climbed to 12, Vanderbilt University Medical Center officials reported on Sunday.

That number, updated on Friday evening, includes eight counties.

The deaths have come relatively early in the flu season, said Dr. William Schaffner, an infectious disease professor at Vanderbilt who tracks cases in Nashville and neighboring counties.

?Throughout last week there were still many patients being hospitalized in Nashville and the surrounding counties,? he said. ?We expect to see more flu over the next several weeks.?...

 

[NS1]

Re: Flu deaths in Middle Tennessee rise to 12

pH1N1 Genetic Sequence
Sparsity
for
Tennessee​

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

Texas communicated two TamiFlu Resistant cases in this week's Public Health report.

 

[NS1]

Re: Flu deaths in Middle Tennessee rise to 12

pH1N1 Child Vaccine Escape
CDC Early 2013
​

Map - Active and Detailed
​

<div style="text-align: center;">
<hr style="width: 30%;" />41 Cases over 43 Sequences<hr style="width: 30%;" /></div>
Introduction

In the 30 days covering 2013-02-28 to 2013-03-29, the <span style="color: #783f04;"><b>United States CDC</b></span> released a total of 43 <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1</span></b> sequences at <strong>GISAID </strong>on 41 human cases<strong> </strong>sampled from October 2012 to February 2013. Geographic surveillance includes <b>America,</b> <b>Africa, Asia </b>and<b> Russia. </b>Although <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1</span></b> in most locales during the 2012-2013 season was the <b><span style="color: #783f04;">minority</span></b> serotype, the sequences in this Analytic Report describe a high level of human-infective diversity and an ease of avian genetic acquisition, including multiple instances demonstrating concentrated transport of <b><span style="color: #660000;">High-CFR</span></b> <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1 </span><span style="color: #783f04;">Upsilon</span></b> polymorphisms onto single sequences.

. . .

Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details​

 

[NS1]

Re: Flu deaths in Middle Tennessee rise to 12

pH1N1 Genetic Sequence
Sparsity
for
Tennessee​

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

pH1N1 TamiFlu Resistance
​

The most recent Tennessee sequence, sampled from a 53 year old woman in March 2013, is Drug Resistant (TmX275 onto a very common Neuraminidase) and displays CrossClade tendencies with Emergent H7N9 homology on the Hemagglutinin.

The Neuraminidase lineage is common; The CrossClade Hemagglutinin lineage was widespread to geographies supporting avian inclusions, e.g. Brazil [EPI484739] and Costa Rica [EPI484980].