tetano
Editor, Senior Moderator
Virology. 2017 Sep 8;512:8-20. doi: 10.1016/j.virol.2017.08.035. [Epub ahead of print]
[h=1]Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017.[/h] Takemae N[SUP]1[/SUP], Tsunekuni R[SUP]1[/SUP], Sharshov K[SUP]2[/SUP], Tanikawa T[SUP]1[/SUP], Uchida Y[SUP]1[/SUP], Ito H[SUP]3[/SUP], Soda K[SUP]3[/SUP], Usui T[SUP]3[/SUP], Sobolev I[SUP]2[/SUP], Shestopalov A[SUP]2[/SUP], Yamaguchi T[SUP]3[/SUP], Mine J[SUP]1[/SUP], Ito T[SUP]3[/SUP], Saito T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively. Six gene segments originated from a putative ancestral clade 2.3.4.4 H5N6 virus that was a possible genetic reassortant among Chinese clade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 3 distinct AIV-derived PA clusters were evident. These results suggest that migratory birds were important in the spread and genetic diversification of clade 2.3.4.4 H5 HPAIVs.
Copyright ? 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Clade 2.3.4.4; H5N6; Highly pathogenic avian influenza A viruses; Poultry; Wild bird
PMID: 28892736 DOI: 10.1016/j.virol.2017.08.035
[h=1]Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017.[/h] Takemae N[SUP]1[/SUP], Tsunekuni R[SUP]1[/SUP], Sharshov K[SUP]2[/SUP], Tanikawa T[SUP]1[/SUP], Uchida Y[SUP]1[/SUP], Ito H[SUP]3[/SUP], Soda K[SUP]3[/SUP], Usui T[SUP]3[/SUP], Sobolev I[SUP]2[/SUP], Shestopalov A[SUP]2[/SUP], Yamaguchi T[SUP]3[/SUP], Mine J[SUP]1[/SUP], Ito T[SUP]3[/SUP], Saito T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively. Six gene segments originated from a putative ancestral clade 2.3.4.4 H5N6 virus that was a possible genetic reassortant among Chinese clade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 3 distinct AIV-derived PA clusters were evident. These results suggest that migratory birds were important in the spread and genetic diversification of clade 2.3.4.4 H5 HPAIVs.
Copyright ? 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Clade 2.3.4.4; H5N6; Highly pathogenic avian influenza A viruses; Poultry; Wild bird
PMID: 28892736 DOI: 10.1016/j.virol.2017.08.035