tetano
Editor, Senior Moderator
Curr Opin Virol. 2011 Dec;1(6):574-581. Epub 2011 Oct 1.
Fitness of neuraminidase inhibitor-resistant influenza A viruses.
Baranovich T, Webster RG, Govorkova EA.
Source
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
Abstract
Antiviral drugs are important components for the control of influenza. The key question is whether antiviral use or natural virus evolution will lead to the emergence of drug-resistant virus with comparable or superior fitness to drug-susceptible counterpart. Currently, neuraminidase (NA) inhibitors (NAIs) are the first choice for influenza prevention and treatment. In this article we will review complex process of the risk assessment for the fitness of NAIs-resistant seasonal H1N1 and H3N2, pandemic 2009 H1N1, and highly pathogenic H5N1 influenza A viruses: identification of antiviral susceptibility, degree of functional NA loss, molecular markers of resistance, and evaluation of replicative ability in vivo, virulence and transmissibility in animal studies (mouse, ferret, and guinea pig models).
Copyright ? 2011 Elsevier B.V. All rights reserved.
PMID:
22440915
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22440915
Fitness of neuraminidase inhibitor-resistant influenza A viruses.
Baranovich T, Webster RG, Govorkova EA.
Source
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
Abstract
Antiviral drugs are important components for the control of influenza. The key question is whether antiviral use or natural virus evolution will lead to the emergence of drug-resistant virus with comparable or superior fitness to drug-susceptible counterpart. Currently, neuraminidase (NA) inhibitors (NAIs) are the first choice for influenza prevention and treatment. In this article we will review complex process of the risk assessment for the fitness of NAIs-resistant seasonal H1N1 and H3N2, pandemic 2009 H1N1, and highly pathogenic H5N1 influenza A viruses: identification of antiviral susceptibility, degree of functional NA loss, molecular markers of resistance, and evaluation of replicative ability in vivo, virulence and transmissibility in animal studies (mouse, ferret, and guinea pig models).
Copyright ? 2011 Elsevier B.V. All rights reserved.
PMID:
22440915
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22440915