tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2019 Mar 29. doi: 10.1111/irv.12644. [Epub ahead of print]
[h=1]Feasibility study for the use of self-collected nasal swabs to identify pathogens among participants of a population-based surveillance system for acute respiratory infections (GrippeWeb-Plus)-Germany, 2016.[/h] Haussig JM[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Targosz A[SUP]4[/SUP], Engelhart S[SUP]4[/SUP], Herzhoff M[SUP]1[/SUP], Prahm K[SUP]1[/SUP], Buda S[SUP]1[/SUP], Nitsche A[SUP]4[/SUP], Haas W[SUP]1[/SUP], Buchholz U[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Internet-based participatory surveillance systems, such as the German GrippeWeb, monitor the frequency of acute respiratory illnesses on population level. In order to interpret syndromic information better, we devised a microbiological feasibility study (GrippeWeb-Plus) to test whether self-collection of anterior nasal swabs is operationally possible, acceptable for participants and can yield valid data.
[h=4]METHODS:[/h] We recruited 103 GrippeWeb participants (73 adults and 30 children) and provided them with a kit, instructions and a questionnaire for each sample. In the first half of 2016, participants took an anterior nasal swab and sent it to the Robert Koch Institute whenever an acute respiratory illness occurred. Reporting of illnesses through the GrippeWeb platform continued as usual. We analysed swabs for the presence of human c-myc-DNA and 22 viral and bacterial pathogens. After the study, we sent participants an evaluation questionnaire. We analysed timeliness, completeness, acceptability and validity.
[h=4]RESULTS:[/h] One hundred and two participants submitted 225 analysable swabs. Ninety per cent of swabs were taken within 3 days of symptom onset. Eighty-nine per cent of swabs had a corresponding reported illness in the GrippeWeb system. Ninety-nine per cent of adults and 96% of children would be willing to participate in a self-swabbing scheme for a longer period. All swabs contained c-myc-DNA. In 119 swabs, we identified any of 14 viruses but no bacteria. The positivity rate of influenza was similar to that in the German physician sentinel.
[h=4]CONCLUSION:[/h] Self-collection of anterior nasal swabs proofed to be feasible, was well accepted by participants, gave valid results and was an informative adjunct to syndromic data.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] epidemiological monitoring; human; influenza; patient generated health data; public health surveillance; respiratory tract infections; self-swabbing
PMID: 30925029 DOI: 10.1111/irv.12644
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[h=1]Feasibility study for the use of self-collected nasal swabs to identify pathogens among participants of a population-based surveillance system for acute respiratory infections (GrippeWeb-Plus)-Germany, 2016.[/h] Haussig JM[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Targosz A[SUP]4[/SUP], Engelhart S[SUP]4[/SUP], Herzhoff M[SUP]1[/SUP], Prahm K[SUP]1[/SUP], Buda S[SUP]1[/SUP], Nitsche A[SUP]4[/SUP], Haas W[SUP]1[/SUP], Buchholz U[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Internet-based participatory surveillance systems, such as the German GrippeWeb, monitor the frequency of acute respiratory illnesses on population level. In order to interpret syndromic information better, we devised a microbiological feasibility study (GrippeWeb-Plus) to test whether self-collection of anterior nasal swabs is operationally possible, acceptable for participants and can yield valid data.
[h=4]METHODS:[/h] We recruited 103 GrippeWeb participants (73 adults and 30 children) and provided them with a kit, instructions and a questionnaire for each sample. In the first half of 2016, participants took an anterior nasal swab and sent it to the Robert Koch Institute whenever an acute respiratory illness occurred. Reporting of illnesses through the GrippeWeb platform continued as usual. We analysed swabs for the presence of human c-myc-DNA and 22 viral and bacterial pathogens. After the study, we sent participants an evaluation questionnaire. We analysed timeliness, completeness, acceptability and validity.
[h=4]RESULTS:[/h] One hundred and two participants submitted 225 analysable swabs. Ninety per cent of swabs were taken within 3 days of symptom onset. Eighty-nine per cent of swabs had a corresponding reported illness in the GrippeWeb system. Ninety-nine per cent of adults and 96% of children would be willing to participate in a self-swabbing scheme for a longer period. All swabs contained c-myc-DNA. In 119 swabs, we identified any of 14 viruses but no bacteria. The positivity rate of influenza was similar to that in the German physician sentinel.
[h=4]CONCLUSION:[/h] Self-collection of anterior nasal swabs proofed to be feasible, was well accepted by participants, gave valid results and was an informative adjunct to syndromic data.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] epidemiological monitoring; human; influenza; patient generated health data; public health surveillance; respiratory tract infections; self-swabbing
PMID: 30925029 DOI: 10.1111/irv.12644
Free full text