Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child

[tetano]

Clin Infect Dis. 2020 Mar 3. pii: ciaa023. doi: 10.1093/cid/ciaa023. [Epub ahead of print] [h=1]Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child.[/h]
Lumby CK[SUP]1[/SUP], Zhao L[SUP]1[/SUP], Oporto M[SUP]2[/SUP], Best T[SUP]2[/SUP], Tutill H[SUP]3[/SUP], Shah D[SUP]3[/SUP], Veys P[SUP]2[/SUP], Williams R[SUP]3[/SUP], Worth A[SUP]2[/SUP], Illingworth CJR[SUP]1,[/SUP][SUP]4[/SUP], Breuer J[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


[h=4]KEYWORDS:[/h] favipiravir; genome sequencing; influenza; zanamivir

PMID: 32124919 DOI: 10.1093/cid/ciaa023