tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2014 Apr 24;10(7). [Epub ahead of print]
Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter.
van Els C1, Mjaaland S2, N?ss L2, Sarkadi J3, Gonczol E3, Smith Korsholm K4, Ulf Hansen J4, de Jonge J1, Kersten G5, Warner J6, Semper A6, Kruiswijk C7, Oftung F2.
Author information
Abstract
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.
KEYWORDS:
COP based vaccine design, correlates of protection, influenza, vaccine development
PMID:
24762738
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24762738
Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter.
van Els C1, Mjaaland S2, N?ss L2, Sarkadi J3, Gonczol E3, Smith Korsholm K4, Ulf Hansen J4, de Jonge J1, Kersten G5, Warner J6, Semper A6, Kruiswijk C7, Oftung F2.
Author information
Abstract
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.
KEYWORDS:
COP based vaccine design, correlates of protection, influenza, vaccine development
PMID:
24762738
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24762738