tetano
Editor, Senior Moderator
FASEB J
. 2022 May;36 Suppl 1.
doi: 10.1096/fasebj.2022.36.S1.R1908.
Autonomic Testing in Collegiate Athletes Following SARS-Cov-2 Infection
J C Luck[SUP] 1 [/SUP], Cheryl Blaha[SUP] 1 [/SUP], Aimee Cauffman[SUP] 1 [/SUP], Amy C Arnold[SUP] 2 [/SUP], Zhaohui Gao[SUP] 1 [/SUP], Takuto Hamaoka[SUP] 1 [/SUP], Lawrence I Sinoway[SUP] 1 [/SUP], Jian Cui[SUP] 1 [/SUP]
Affiliations
Abstract
To date, more than 46 million people in the United States have contracted the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. Over 700 thousand total cases have been linked to American colleges and universities. Post-acute sequelae of SARS-CoV-2 infection may affect varied systems. It was reported that sympathetic nerve activity following SARS-CoV-2 infection was elevated in young individuals. Cardiovascular autonomic function post-acute SARS-CoV-2 infection in other populations such as athletes, however, has not been thoroughly investigated. Collegiate athletes are a unique population given that they might have a high level of physical fitness before the infection. The present study examined 16 collegiate athletes (12 men and 4 women, age: 20±1 yrs, height: 181±10 cm, weight: 81±18 kg) who were evaluated ~2 weeks after testing positive for SARS-CoV-2 by polymerase chain reaction assay. These subjects were asymptomatic or with mild/moderate symptoms during infection. None of the subjects had been hospitalized for COVID-19 and all subjects were asymptomatic at the time of the study. Beat-by-beat blood pressure (BP) with Finometer, and heart rate (HR) from ECG were recorded during 10 minutes of supine rest, Valsalva maneuver, slow breathing (6 breaths/min), handgrip exercise, and 10 minutes of standing. BP, HR, heart rate variability (HRV), and cardiac baroreflex sensitivity (CBRS), and venous blood aldosterone and renin levels were analyzed. The vagal tone index from HRV in 3 of 16 athletes was lower than normative values. The responses in BP to Valsalva maneuver during phases IIa (i.e., "early") and IIb (i.e., "late") were mildly abnormal in 4 athletes and moderately abnormal in one athlete. The Valsalva ratio was below the normal range in 6 athletes. In response to slow breathing, the respiratory sinus arrhythmia amplitude was below the normal range in 3 athletes. In response to handgrip exercise, one athlete had an atypical response where BP decreased while HR was increased from baseline. Three of the subjects were unable to tolerate an orthostatic challenge for 10 minutes. Four out of 16 athletes had abnormally elevated renin activity and 1 out 16 elevated aldosterone levels. It is important to note that while several athletes had abnormal responses to the various autonomic tests, these abnormalities did not correlate with symptoms seen during the infection. Our data suggest that SARS-CoV-2 infection may reduce parasympathetic and increase sympathetic tone and may contribute to the autonomic disfunction associated in a subset of collegiate athletes even after recovering from COVID-19. This study provides further evidence for potential long-term cardiovascular autonomic effects of Covid-19 infection even in healthy young trained athletes. Further studies with a larger patient population as well as suitable healthy control subjects are warranted.
. 2022 May;36 Suppl 1.
doi: 10.1096/fasebj.2022.36.S1.R1908.
Autonomic Testing in Collegiate Athletes Following SARS-Cov-2 Infection
J C Luck[SUP] 1 [/SUP], Cheryl Blaha[SUP] 1 [/SUP], Aimee Cauffman[SUP] 1 [/SUP], Amy C Arnold[SUP] 2 [/SUP], Zhaohui Gao[SUP] 1 [/SUP], Takuto Hamaoka[SUP] 1 [/SUP], Lawrence I Sinoway[SUP] 1 [/SUP], Jian Cui[SUP] 1 [/SUP]
Affiliations
- PMID: 35557060
- DOI: 10.1096/fasebj.2022.36.S1.R1908
Abstract
To date, more than 46 million people in the United States have contracted the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. Over 700 thousand total cases have been linked to American colleges and universities. Post-acute sequelae of SARS-CoV-2 infection may affect varied systems. It was reported that sympathetic nerve activity following SARS-CoV-2 infection was elevated in young individuals. Cardiovascular autonomic function post-acute SARS-CoV-2 infection in other populations such as athletes, however, has not been thoroughly investigated. Collegiate athletes are a unique population given that they might have a high level of physical fitness before the infection. The present study examined 16 collegiate athletes (12 men and 4 women, age: 20±1 yrs, height: 181±10 cm, weight: 81±18 kg) who were evaluated ~2 weeks after testing positive for SARS-CoV-2 by polymerase chain reaction assay. These subjects were asymptomatic or with mild/moderate symptoms during infection. None of the subjects had been hospitalized for COVID-19 and all subjects were asymptomatic at the time of the study. Beat-by-beat blood pressure (BP) with Finometer, and heart rate (HR) from ECG were recorded during 10 minutes of supine rest, Valsalva maneuver, slow breathing (6 breaths/min), handgrip exercise, and 10 minutes of standing. BP, HR, heart rate variability (HRV), and cardiac baroreflex sensitivity (CBRS), and venous blood aldosterone and renin levels were analyzed. The vagal tone index from HRV in 3 of 16 athletes was lower than normative values. The responses in BP to Valsalva maneuver during phases IIa (i.e., "early") and IIb (i.e., "late") were mildly abnormal in 4 athletes and moderately abnormal in one athlete. The Valsalva ratio was below the normal range in 6 athletes. In response to slow breathing, the respiratory sinus arrhythmia amplitude was below the normal range in 3 athletes. In response to handgrip exercise, one athlete had an atypical response where BP decreased while HR was increased from baseline. Three of the subjects were unable to tolerate an orthostatic challenge for 10 minutes. Four out of 16 athletes had abnormally elevated renin activity and 1 out 16 elevated aldosterone levels. It is important to note that while several athletes had abnormal responses to the various autonomic tests, these abnormalities did not correlate with symptoms seen during the infection. Our data suggest that SARS-CoV-2 infection may reduce parasympathetic and increase sympathetic tone and may contribute to the autonomic disfunction associated in a subset of collegiate athletes even after recovering from COVID-19. This study provides further evidence for potential long-term cardiovascular autonomic effects of Covid-19 infection even in healthy young trained athletes. Further studies with a larger patient population as well as suitable healthy control subjects are warranted.