tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2024 Jun 13.
doi: 10.1080/14760584.2024.2367457. Online ahead of print. Mapping and ranking outcomes for the evaluation of seasonal influenza vaccine efficacy and effectiveness: a delphi study
Chiara de Waure[SUP] 1 [/SUP], Elisabetta Alti[SUP] 2 [/SUP], Vincenzo Baldo[SUP] 3 [/SUP], Paolo Bonanni[SUP] 4 [/SUP], Michele Conversano[SUP] 5 [/SUP], Alberto Fedele[SUP] 6 [/SUP], Giovanni Gabutti[SUP] 7 [/SUP], Roberto Ieraci[SUP] 8 [/SUP], Francesco Landi[SUP] 9 [/SUP], Raffaele Landolfi[SUP] 10 [/SUP], Andrea Orsi[SUP] 11 12 [/SUP], Caterina Rizzo[SUP] 13 [/SUP], Alessandro Rossi[SUP] 14 [/SUP], Alberto Villani[SUP] 15 16 [/SUP], Francesco Vitale[SUP] 17 [/SUP], Alexander Domnich[SUP] 12 [/SUP]
Affiliations
Background: Protection provided by seasonal influenza vaccination (SIV) may be measured against numerous outcomes and their heterogeneity may hamper decision-making. The aim of this study was to explore outcomes used for estimation of SIV efficacy/effectiveness (VE) and obtain expert consensus on their importance.
Research design and methods: An umbrella review was first conducted to collect and map outcomes considered in systematic reviews of SIV VE. A Delphi study was then performed to reach expert convergence on the importance of single outcomes, measured on a 9-point Likert scale, in principal target groups, namely children, working-age adults, older adults, subjects with co-morbidities and pregnant women.
Results: Literature review identified 489 outcomes. Following data reduction, 20 outcomes were selected for the Delphi process. After two Delphi rounds and a final consensus meeting, convergence was reached. All 20 outcomes were judged important or critically important. More severe outcomes, such as influenza-related hospital encounters and mortality with or without laboratory confirmation, were generally top-ranked across all target groups (median scores ≥ 8 out of 9).
Conclusions: Rather than focusing on laboratory-confirmed infection per se, experimental and observational VE studies should include more severe influenza-related outcomes because they are expected to exercise a greater impact on decision-making.
Keywords: Delphi method; Influenza; Influenza vaccines; Outcome assessment; Vaccine effectiveness; Vaccine efficacy.
. 2024 Jun 13.
doi: 10.1080/14760584.2024.2367457. Online ahead of print. Mapping and ranking outcomes for the evaluation of seasonal influenza vaccine efficacy and effectiveness: a delphi study
Chiara de Waure[SUP] 1 [/SUP], Elisabetta Alti[SUP] 2 [/SUP], Vincenzo Baldo[SUP] 3 [/SUP], Paolo Bonanni[SUP] 4 [/SUP], Michele Conversano[SUP] 5 [/SUP], Alberto Fedele[SUP] 6 [/SUP], Giovanni Gabutti[SUP] 7 [/SUP], Roberto Ieraci[SUP] 8 [/SUP], Francesco Landi[SUP] 9 [/SUP], Raffaele Landolfi[SUP] 10 [/SUP], Andrea Orsi[SUP] 11 12 [/SUP], Caterina Rizzo[SUP] 13 [/SUP], Alessandro Rossi[SUP] 14 [/SUP], Alberto Villani[SUP] 15 16 [/SUP], Francesco Vitale[SUP] 17 [/SUP], Alexander Domnich[SUP] 12 [/SUP]
Affiliations
- PMID: 38869028
- DOI: 10.1080/14760584.2024.2367457
Background: Protection provided by seasonal influenza vaccination (SIV) may be measured against numerous outcomes and their heterogeneity may hamper decision-making. The aim of this study was to explore outcomes used for estimation of SIV efficacy/effectiveness (VE) and obtain expert consensus on their importance.
Research design and methods: An umbrella review was first conducted to collect and map outcomes considered in systematic reviews of SIV VE. A Delphi study was then performed to reach expert convergence on the importance of single outcomes, measured on a 9-point Likert scale, in principal target groups, namely children, working-age adults, older adults, subjects with co-morbidities and pregnant women.
Results: Literature review identified 489 outcomes. Following data reduction, 20 outcomes were selected for the Delphi process. After two Delphi rounds and a final consensus meeting, convergence was reached. All 20 outcomes were judged important or critically important. More severe outcomes, such as influenza-related hospital encounters and mortality with or without laboratory confirmation, were generally top-ranked across all target groups (median scores ≥ 8 out of 9).
Conclusions: Rather than focusing on laboratory-confirmed infection per se, experimental and observational VE studies should include more severe influenza-related outcomes because they are expected to exercise a greater impact on decision-making.
Keywords: Delphi method; Influenza; Influenza vaccines; Outcome assessment; Vaccine effectiveness; Vaccine efficacy.