tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2021 Jan 22;1-9.
doi: 10.1080/14760584.2021.1874927. Online ahead of print.
Evaluation of influenza vaccination efficacy in reducing influenza-related complications and excess mortality in Northern Italy (2014-2017)
Giuseppe Marano[SUP] 1 [/SUP], Patrizia Boracchi[SUP] 1 [/SUP], Ester Luconi[SUP] 2 [/SUP], Elena Pariani[SUP] 3 [/SUP], Laura Pellegrinelli[SUP] 3 [/SUP], Cristina Galli[SUP] 3 [/SUP], Cecilia E Gandolfi[SUP] 3 [/SUP], Michele Magoni[SUP] 4 [/SUP], Antonio Piro[SUP] 4 [/SUP], Carmelo Scarcella[SUP] 4 [/SUP], Silvana Castaldi[SUP] 2 3 [/SUP], Elia M Biganzoli[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: The main objective of this study was to estimate the efficacy of influenza vaccination in reducing influenza-attributable hospitalization and emergency room (ER) admission for severe complications and influenza-attributable excess mortality in individuals ≥65 years of age.
Methods: We analyzed the ≥65 years-old community (n = 952,822) afferent to the Brescia (Northern Italy) Health Protection Agency, considered an Italian population reference, to evaluate the efficacy of influenza vaccination (seasons 2014-17) in reducing deaths, ER-admissions, and hospitalizations for influenza-related complications in the elderly.
Results: A protective effect of influenza vaccination emerged in reducing hospitalization and ER admission for diseases of the respiratory system and for death from all causes in people ≥65 years. The major effect of influenza vaccination was the reduction in risk of death from all causes, increasing with age and comorbidity.
Conclusion: Influenza vaccination has reduced the number of ER admissions and hospitalizations caused by influenza-related complications and has prevented death among high-risk groups in elderly ≥65 years, resulting in social and public health cost savings. Stronger or new vaccination strategies are needed to improve vaccination rates among the elderly.
Keywords: Efficacy of influenza vaccination; cardiac disease and stroke; death from all causes; diseases of the respiratory system; elderly.
. 2021 Jan 22;1-9.
doi: 10.1080/14760584.2021.1874927. Online ahead of print.
Evaluation of influenza vaccination efficacy in reducing influenza-related complications and excess mortality in Northern Italy (2014-2017)
Giuseppe Marano[SUP] 1 [/SUP], Patrizia Boracchi[SUP] 1 [/SUP], Ester Luconi[SUP] 2 [/SUP], Elena Pariani[SUP] 3 [/SUP], Laura Pellegrinelli[SUP] 3 [/SUP], Cristina Galli[SUP] 3 [/SUP], Cecilia E Gandolfi[SUP] 3 [/SUP], Michele Magoni[SUP] 4 [/SUP], Antonio Piro[SUP] 4 [/SUP], Carmelo Scarcella[SUP] 4 [/SUP], Silvana Castaldi[SUP] 2 3 [/SUP], Elia M Biganzoli[SUP] 1 [/SUP]
Affiliations
- PMID: 33480821
- DOI: 10.1080/14760584.2021.1874927
Abstract
Objective: The main objective of this study was to estimate the efficacy of influenza vaccination in reducing influenza-attributable hospitalization and emergency room (ER) admission for severe complications and influenza-attributable excess mortality in individuals ≥65 years of age.
Methods: We analyzed the ≥65 years-old community (n = 952,822) afferent to the Brescia (Northern Italy) Health Protection Agency, considered an Italian population reference, to evaluate the efficacy of influenza vaccination (seasons 2014-17) in reducing deaths, ER-admissions, and hospitalizations for influenza-related complications in the elderly.
Results: A protective effect of influenza vaccination emerged in reducing hospitalization and ER admission for diseases of the respiratory system and for death from all causes in people ≥65 years. The major effect of influenza vaccination was the reduction in risk of death from all causes, increasing with age and comorbidity.
Conclusion: Influenza vaccination has reduced the number of ER admissions and hospitalizations caused by influenza-related complications and has prevented death among high-risk groups in elderly ≥65 years, resulting in social and public health cost savings. Stronger or new vaccination strategies are needed to improve vaccination rates among the elderly.
Keywords: Efficacy of influenza vaccination; cardiac disease and stroke; death from all causes; diseases of the respiratory system; elderly.