tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2021 Dec 8.
doi: 10.1080/14760584.2022.2013820. Online ahead of print.
Effectiveness of maternal vaccination with quadrivalent inactivated influenza vaccine in pregnant women and their infants in 2019-2020
Helena C Maltezou[SUP] 1 [/SUP], Sofoklis Stavros[SUP] 2 [/SUP], George Asimakopoulos[SUP] 2 [/SUP], Vasilios Pergialiotis[SUP] 2 [/SUP], Vasilios Raftopoulos[SUP] 3 [/SUP], Michael A Talias[SUP] 4 [/SUP], Androula Pavli[SUP] 5 [/SUP], George Daskalakis[SUP] 2 [/SUP], Michael Sindos[SUP] 2 [/SUP], Pelopidas Koutroumanis[SUP] 2 [/SUP], Marianna Theodora[SUP] 2 [/SUP], Panagiotis Antsaklis[SUP] 2 [/SUP], Evangelos Kostis[SUP] 6 [/SUP], Evangelia Stratiki[SUP] 7 [/SUP], Athanasios Kossyvakis[SUP] 8 [/SUP], Maria Theodoridou[SUP] 9 [/SUP], Andreas Mentis[SUP] 8 [/SUP], Petros Drakakis[SUP] 2 [/SUP], Dimitrios Loutradis[SUP] 2 [/SUP], Alexandros Rodolakis[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: Influenza is associated with an increased risk for serious illness, hospitalization and death in pregnant women and young infants. Our aim was to estimate the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during 2019-2020 influenza season.
Methods: A QIV vaccine was offered to pregnant women followed in a maternity hospital. Women were contacted weekly during the influenza season and asked about symptoms. Polymerase chain reaction testing in pharyngeal samples was offered to pregnant women and infants with influenza-like illness. A Bayesian beta-binomial model was used.
Results: We studied 636 pregnant women (406 vaccinated and 230 unvaccinated) and 474 infants (281 of mothers vaccinated in pregnancy and 193 of unvaccinated mothers). Using a Bayesian beta-binomial model, it was estimated that influenza vaccination of pregnant women reduced their logit to develop laboratory-confirmed influenza by -4.2 (95% CI -3,7 -4,7) and the logit of their infants to develop laboratory-confirmed influenza by -4.2 (95% CI -3.6, -4.9). The QIV effectiveness against laboratory-confirmed influenza was 43.5% in pregnant women and 31.4% in infants.
Conclusion: Maternal influenza vaccination with QIV in pregnancy reduced the odds of pregnant women and their infants to develop influenza.
Clinical trial registration: www.clinicaltrials.gov identifier is NCT04723771.
Keywords: effectiveness; infants; influenza vaccination; pregnant woman; quadrivalent influenza vaccine.
. 2021 Dec 8.
doi: 10.1080/14760584.2022.2013820. Online ahead of print.
Effectiveness of maternal vaccination with quadrivalent inactivated influenza vaccine in pregnant women and their infants in 2019-2020
Helena C Maltezou[SUP] 1 [/SUP], Sofoklis Stavros[SUP] 2 [/SUP], George Asimakopoulos[SUP] 2 [/SUP], Vasilios Pergialiotis[SUP] 2 [/SUP], Vasilios Raftopoulos[SUP] 3 [/SUP], Michael A Talias[SUP] 4 [/SUP], Androula Pavli[SUP] 5 [/SUP], George Daskalakis[SUP] 2 [/SUP], Michael Sindos[SUP] 2 [/SUP], Pelopidas Koutroumanis[SUP] 2 [/SUP], Marianna Theodora[SUP] 2 [/SUP], Panagiotis Antsaklis[SUP] 2 [/SUP], Evangelos Kostis[SUP] 6 [/SUP], Evangelia Stratiki[SUP] 7 [/SUP], Athanasios Kossyvakis[SUP] 8 [/SUP], Maria Theodoridou[SUP] 9 [/SUP], Andreas Mentis[SUP] 8 [/SUP], Petros Drakakis[SUP] 2 [/SUP], Dimitrios Loutradis[SUP] 2 [/SUP], Alexandros Rodolakis[SUP] 2 [/SUP]
Affiliations
- PMID: 34878959
- DOI: 10.1080/14760584.2022.2013820
Abstract
Objectives: Influenza is associated with an increased risk for serious illness, hospitalization and death in pregnant women and young infants. Our aim was to estimate the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during 2019-2020 influenza season.
Methods: A QIV vaccine was offered to pregnant women followed in a maternity hospital. Women were contacted weekly during the influenza season and asked about symptoms. Polymerase chain reaction testing in pharyngeal samples was offered to pregnant women and infants with influenza-like illness. A Bayesian beta-binomial model was used.
Results: We studied 636 pregnant women (406 vaccinated and 230 unvaccinated) and 474 infants (281 of mothers vaccinated in pregnancy and 193 of unvaccinated mothers). Using a Bayesian beta-binomial model, it was estimated that influenza vaccination of pregnant women reduced their logit to develop laboratory-confirmed influenza by -4.2 (95% CI -3,7 -4,7) and the logit of their infants to develop laboratory-confirmed influenza by -4.2 (95% CI -3.6, -4.9). The QIV effectiveness against laboratory-confirmed influenza was 43.5% in pregnant women and 31.4% in infants.
Conclusion: Maternal influenza vaccination with QIV in pregnancy reduced the odds of pregnant women and their infants to develop influenza.
Clinical trial registration: www.clinicaltrials.gov identifier is NCT04723771.
Keywords: effectiveness; infants; influenza vaccination; pregnant woman; quadrivalent influenza vaccine.