tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2020 Jun 8.
doi: 10.1080/14760584.2020.1777861. Online ahead of print.
Development of Broadly Reactive Influenza Vaccines by Targeting the Conserved Regions of the Hemagglutinin Stem and Head Domains
Nina M C de Jong[SUP] 1 [/SUP], Aafke Aartse[SUP] 1 2 [/SUP], Marit J van Gils[SUP] 1 [/SUP], Dirk Eggink[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Influenza virus infections cause serious illness in millions of people each year. Although influenza virus vaccines are available, they are not optimally effective due to mismatches between the influenza virus strains used for the vaccine and the circulating strains. To improve protection by vaccines, a broadly protective or universal vaccine may be required. Strategies to develop universal vaccines aim to elicit broadly reactive antibodies, which target regions on the viral hemagglutinin (HA) protein which are conserved between strains. Broadly reactive antibodies have helped to identify such targets and can guide the design of such a vaccine.
Areas covered: The first part of this review provides an in-depth overview of broadly reactive anti-HA antibodies, discussing their origin, breadth and their mechanisms of protection. The second part discusses the technical design and mode of action of potential universal vaccine candidates that aim to elicit these broadly reactive antibodies and provide protection against a majority of influenza strains.
Expert opinion: While great strides have been made in the development of universal influenza vaccine candidates, real-life use still requires the improvement of their stability and ease of production, determine their efficacy in human trials and enhance their breadth of protection.
. 2020 Jun 8.
doi: 10.1080/14760584.2020.1777861. Online ahead of print.
Development of Broadly Reactive Influenza Vaccines by Targeting the Conserved Regions of the Hemagglutinin Stem and Head Domains
Nina M C de Jong[SUP] 1 [/SUP], Aafke Aartse[SUP] 1 2 [/SUP], Marit J van Gils[SUP] 1 [/SUP], Dirk Eggink[SUP] 1 [/SUP]
Affiliations
- PMID: 32510256
- DOI: 10.1080/14760584.2020.1777861
Abstract
Introduction: Influenza virus infections cause serious illness in millions of people each year. Although influenza virus vaccines are available, they are not optimally effective due to mismatches between the influenza virus strains used for the vaccine and the circulating strains. To improve protection by vaccines, a broadly protective or universal vaccine may be required. Strategies to develop universal vaccines aim to elicit broadly reactive antibodies, which target regions on the viral hemagglutinin (HA) protein which are conserved between strains. Broadly reactive antibodies have helped to identify such targets and can guide the design of such a vaccine.
Areas covered: The first part of this review provides an in-depth overview of broadly reactive anti-HA antibodies, discussing their origin, breadth and their mechanisms of protection. The second part discusses the technical design and mode of action of potential universal vaccine candidates that aim to elicit these broadly reactive antibodies and provide protection against a majority of influenza strains.
Expert opinion: While great strides have been made in the development of universal influenza vaccine candidates, real-life use still requires the improvement of their stability and ease of production, determine their efficacy in human trials and enhance their breadth of protection.