tetano
Editor, Senior Moderator
Expert Rev Pharmacoecon Outcomes Res
. 2024 Jun 8.
doi: 10.1080/14737167.2024.2365421. Online ahead of print. A cost-effectiveness analysis of reduced viral transmission with baloxavir marboxil versus oseltamivir or no treatment for seasonal and pandemic influenza management in the United Kingdom
Svenn Alexander Kommandantvold[SUP] 1 [/SUP], Annabelle Lemenuel-Diot[SUP] 1 [/SUP], Chris Skedgel[SUP] 2 [/SUP], Richard Pitman[SUP] 3 [/SUP], Peter Rouse[SUP] 4 [/SUP], Hassan Zaraket[SUP] 4 [/SUP], Hao Zhou[SUP] 5 [/SUP], Marie-Helene Blanchet Zumofen[SUP] 1 [/SUP]
Affiliations
Background: Baloxavir marboxil is an oral, single-dose, cap-dependent endonuclease inhibitor that reduces the duration of influenza symptoms and rapidly stops viral shedding. We developed a susceptible, exposed, infected, recovered (SEIR) model to inform a cost-effectiveness model (CEM) of baloxavir versus oseltamivir or no antiviral treatment in the UK.
Research design and methods: The SEIR model estimated the attack rates among otherwise healthy and high-risk individuals in seasonal and pandemic settings. The CEM assumed that a proportion of infected patients would receive antiviral treatment. Results were reported at the population level (per 10,000 at risk of infection).
Results: The SEIR model estimated greater reductions in infections with baloxavir. In a seasonal setting, baloxavir provided incremental cost-effectiveness ratios (ICERs) of £1884 per quality-adjusted life-year (QALY) gained versus oseltamivir and a dominant cost-effectiveness position versus no antiviral treatment in the total population; ICERs of £2574/QALY versus oseltamivir and £128/QALY versus no antiviral treatment were seen in the high-risk population. Baloxavir was also cost-effective versus oseltamivir or no antiviral treatment and reduced population-level health system occupancy concerns during a pandemic.
Conclusion: Baloxavir treatment resulted in the fewest influenza cases and was cost-effective versus oseltamivir or no antiviral treatment from a UK National Health Service perspective.
Keywords: Antiviral treatment; United Kingdom; baloxavir marboxil; cost-effectiveness; influenza; oseltamivir.
. 2024 Jun 8.
doi: 10.1080/14737167.2024.2365421. Online ahead of print. A cost-effectiveness analysis of reduced viral transmission with baloxavir marboxil versus oseltamivir or no treatment for seasonal and pandemic influenza management in the United Kingdom
Svenn Alexander Kommandantvold[SUP] 1 [/SUP], Annabelle Lemenuel-Diot[SUP] 1 [/SUP], Chris Skedgel[SUP] 2 [/SUP], Richard Pitman[SUP] 3 [/SUP], Peter Rouse[SUP] 4 [/SUP], Hassan Zaraket[SUP] 4 [/SUP], Hao Zhou[SUP] 5 [/SUP], Marie-Helene Blanchet Zumofen[SUP] 1 [/SUP]
Affiliations
- PMID: 38850520
- DOI: 10.1080/14737167.2024.2365421
Background: Baloxavir marboxil is an oral, single-dose, cap-dependent endonuclease inhibitor that reduces the duration of influenza symptoms and rapidly stops viral shedding. We developed a susceptible, exposed, infected, recovered (SEIR) model to inform a cost-effectiveness model (CEM) of baloxavir versus oseltamivir or no antiviral treatment in the UK.
Research design and methods: The SEIR model estimated the attack rates among otherwise healthy and high-risk individuals in seasonal and pandemic settings. The CEM assumed that a proportion of infected patients would receive antiviral treatment. Results were reported at the population level (per 10,000 at risk of infection).
Results: The SEIR model estimated greater reductions in infections with baloxavir. In a seasonal setting, baloxavir provided incremental cost-effectiveness ratios (ICERs) of £1884 per quality-adjusted life-year (QALY) gained versus oseltamivir and a dominant cost-effectiveness position versus no antiviral treatment in the total population; ICERs of £2574/QALY versus oseltamivir and £128/QALY versus no antiviral treatment were seen in the high-risk population. Baloxavir was also cost-effective versus oseltamivir or no antiviral treatment and reduced population-level health system occupancy concerns during a pandemic.
Conclusion: Baloxavir treatment resulted in the fewest influenza cases and was cost-effective versus oseltamivir or no antiviral treatment from a UK National Health Service perspective.
Keywords: Antiviral treatment; United Kingdom; baloxavir marboxil; cost-effectiveness; influenza; oseltamivir.