tetano
Editor, Senior Moderator
Epidemiol Infect. 2013 Mar 19:1-9. [Epub ahead of print]
Experimental infection of dogs with H3N2 canine influenza virus from China.
Zeng XJ, Lin Y, Zhao YB, Lu CP, Liu YJ.
Source
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Abstract
SUMMARY Canine influenza virus (CIV) is an emerging pathogen that causes acute respiratory disease in dogs. The aim of this study was to investigate the pathogenicity of A/canine/Jiangsu/06/2010 (H3N2) virus isolated in China. Nine dogs were inoculated intranasally with 107?95 of 50% egg infectious dose (EID50) of the virus. The onset of clinical signs and virus shedding was observed on day 1 post-infection (p.i.). The peak clinical score occurred between days 4 and 6 p.i. The experimentally infected dogs were found to shed virus not only via the respiratory tract but also via the digestive tract. Viral RNA could be detected in multiple organs including the trachea, lung, liver, spleen, kidney, brain and duodenum. All the sampled organs from infected dogs showed significant lesions and viral antigen staining. The results differed from those reporting using previous CIV strains; the Chinese isolate could induce extrapulmonary infection and cause extensive lesions in dogs.
PMID:
23510585
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23510585
Experimental infection of dogs with H3N2 canine influenza virus from China.
Zeng XJ, Lin Y, Zhao YB, Lu CP, Liu YJ.
Source
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Abstract
SUMMARY Canine influenza virus (CIV) is an emerging pathogen that causes acute respiratory disease in dogs. The aim of this study was to investigate the pathogenicity of A/canine/Jiangsu/06/2010 (H3N2) virus isolated in China. Nine dogs were inoculated intranasally with 107?95 of 50% egg infectious dose (EID50) of the virus. The onset of clinical signs and virus shedding was observed on day 1 post-infection (p.i.). The peak clinical score occurred between days 4 and 6 p.i. The experimentally infected dogs were found to shed virus not only via the respiratory tract but also via the digestive tract. Viral RNA could be detected in multiple organs including the trachea, lung, liver, spleen, kidney, brain and duodenum. All the sampled organs from infected dogs showed significant lesions and viral antigen staining. The results differed from those reporting using previous CIV strains; the Chinese isolate could induce extrapulmonary infection and cause extensive lesions in dogs.
PMID:
23510585
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23510585