tetano
Editor, Senior Moderator
Cir Cir. 2011 Sep;79(5):409-16.
[Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit].
[Article in Spanish]
Carrillo-Esper R, Sosa-Garc?a JO, Arch-Tirado E.
Source
Unidad de Terapia Intensiva, Fundaci?n Cl?nica M?dica Sur, M?xico, D. F., Mexico. revistacma@yahoo.com.mx.
Abstract
Background: At the beginning of the second trimester of 2009 there was an influenza A (H1N1) outbreak. The aim of this study is to describe the clinical presentation and mortality of the severe form of pneumonia in patients with human influenza A H1N1. Methods: We conducted a retrospective review of all files of confirmed and suspected patients with severe human influenza A (H1N1) pneumonia. Results: We studied 26 patients admitted to the ICU from April 1 to December 31, 2009, among which 16 were males (61.54%) and 10 females (38.46%) with an average age of 52.26 ? 15.48 years. The time of onset of symptoms to admission to the ICU was 6.3 ? 3.19 days. The most frequent symptoms and signs were salmonated sputum (47%), chills (45%), dry cough (44%) and myalgia (42%). The mortality rate was 19.23%. The treatment was based on antiviral therapy, modulating inflammation and ventilatory techniques to optimize oxygenation. There was an association between combined therapy based on methylprednisolone, activated protein C and statins with a better survival (p = 0.05). Conclusions: Pneumonia virus of human influenza A (H1N1) is associated with high morbidity and mortality. According to our results, it is recommended to make an early diagnosis and to initiate a treatment regimen based on treatment bundles designed to optimize oxygenation, reduce viral load and modulate inflammation.
PMID:
22385760
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22385760
[Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit].
[Article in Spanish]
Carrillo-Esper R, Sosa-Garc?a JO, Arch-Tirado E.
Source
Unidad de Terapia Intensiva, Fundaci?n Cl?nica M?dica Sur, M?xico, D. F., Mexico. revistacma@yahoo.com.mx.
Abstract
Background: At the beginning of the second trimester of 2009 there was an influenza A (H1N1) outbreak. The aim of this study is to describe the clinical presentation and mortality of the severe form of pneumonia in patients with human influenza A H1N1. Methods: We conducted a retrospective review of all files of confirmed and suspected patients with severe human influenza A (H1N1) pneumonia. Results: We studied 26 patients admitted to the ICU from April 1 to December 31, 2009, among which 16 were males (61.54%) and 10 females (38.46%) with an average age of 52.26 ? 15.48 years. The time of onset of symptoms to admission to the ICU was 6.3 ? 3.19 days. The most frequent symptoms and signs were salmonated sputum (47%), chills (45%), dry cough (44%) and myalgia (42%). The mortality rate was 19.23%. The treatment was based on antiviral therapy, modulating inflammation and ventilatory techniques to optimize oxygenation. There was an association between combined therapy based on methylprednisolone, activated protein C and statins with a better survival (p = 0.05). Conclusions: Pneumonia virus of human influenza A (H1N1) is associated with high morbidity and mortality. According to our results, it is recommended to make an early diagnosis and to initiate a treatment regimen based on treatment bundles designed to optimize oxygenation, reduce viral load and modulate inflammation.
PMID:
22385760
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22385760