tetano
Editor, Senior Moderator
J Virol. 2013 Feb 6. [Epub ahead of print]
Evolution of equine influenza virus in vaccinated horses.
Murcia PR, Baillie GJ, Stack JC, Jervis C, Elton D, Mumford JA, Daly J, Kellam P, Grenfell BT, Holmes EC, Wood JL.
Source
Medical Research Council-University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Abstract
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo we studied the intra- and inter-host evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity was similar to that in na?ve horses, intra-host bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
PMID:
23388708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23388708
Evolution of equine influenza virus in vaccinated horses.
Murcia PR, Baillie GJ, Stack JC, Jervis C, Elton D, Mumford JA, Daly J, Kellam P, Grenfell BT, Holmes EC, Wood JL.
Source
Medical Research Council-University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Abstract
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo we studied the intra- and inter-host evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity was similar to that in na?ve horses, intra-host bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
PMID:
23388708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23388708