tetano
Editor, Senior Moderator
Transbound Emerg Dis. 2010 Jun 10. [Epub ahead of print]
Evidence Obtained from anova to Reason Cross-species Infection and Cross-subtype Mutation in Neuraminidases of Influenza A Viruses.
Yan S, Wu G.
National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, China.
Abstract
Summary The current pandemic of A/H1N1 influenza raises a serious question on cross-species infection and cross-subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross-species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross-species barrier in some species, and the intra-species variation is larger than the inter-species variation in some species hosting the viruses, and the cross-subtype mutation is possible because there is no cross-subtype barrier in some subtypes and the intra-subtype variation is larger than the inter-subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
PMID: 20545912 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20545912
Evidence Obtained from anova to Reason Cross-species Infection and Cross-subtype Mutation in Neuraminidases of Influenza A Viruses.
Yan S, Wu G.
National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, China.
Abstract
Summary The current pandemic of A/H1N1 influenza raises a serious question on cross-species infection and cross-subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross-species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross-species barrier in some species, and the intra-species variation is larger than the inter-species variation in some species hosting the viruses, and the cross-subtype mutation is possible because there is no cross-subtype barrier in some subtypes and the intra-subtype variation is larger than the inter-subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
PMID: 20545912 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20545912