tetano
Editor, Senior Moderator
J Infect Dis. 2018 Jan 6. doi: 10.1093/infdis/jix509. [Epub ahead of print]
[h=1]Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages.[/h] Laurie KL[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Horman W[SUP]2[/SUP], Carolan LA[SUP]1[/SUP], Chan KF[SUP]1[/SUP], Layton D[SUP]4[/SUP], Bean A[SUP]4[/SUP], Vijaykrishna D[SUP]5,[/SUP][SUP]6[/SUP], Reading PC[SUP]1,[/SUP][SUP]2[/SUP], McCaw JM[SUP]7,[/SUP][SUP]8[/SUP], Barr IG[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Two influenza B virus lineages, B/Victoria and B/Yamagata, cocirculate in the human population. While the lineages are serologically distinct, cross-reactive responses to both lineages have been detected. Viral interference describes the situation whereby infection with one virus limits infection and replication of a second virus. We investigated the potential for viral interference between the influenza B virus lineages.
[h=4]Methods:[/h] Ferrets were infected and then challenged 3, 10, or 28 days later with pairs of influenza B/Victoria and B/Yamagata viruses.
[h=4]Results:[/h] Viral interference occurred at challenge intervals of 3 and 10 days and occasionally at 28 days. At the longer interval, shedding of challenge virus was reduced, and this correlated with cross-reactive interferon γ responses from lymph nodes from virus-infected animals. Viruses from both lineages could prevent or significantly limit subsequent infection with a virus from the other lineage. Coinfections were rare, indicating the potential for reassortment between lineages is limited.
[h=4]Conclusions:[/h] These data suggest that innate and cross-reactive immunity mediate viral interference and that this may contribute to the dominance of a specific influenza B virus lineage in any given influenza season. Furthermore, infection with one influenza B virus lineage may be beneficial in protecting against subsequent infection with either influenza B virus lineage.
[h=4]KEYWORDS:[/h] Viral interference; cross-protection; dominance; ferret; influenza; influenza B; lineage
PMID: 29325138 DOI: 10.1093/infdis/jix509
[h=1]Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages.[/h] Laurie KL[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Horman W[SUP]2[/SUP], Carolan LA[SUP]1[/SUP], Chan KF[SUP]1[/SUP], Layton D[SUP]4[/SUP], Bean A[SUP]4[/SUP], Vijaykrishna D[SUP]5,[/SUP][SUP]6[/SUP], Reading PC[SUP]1,[/SUP][SUP]2[/SUP], McCaw JM[SUP]7,[/SUP][SUP]8[/SUP], Barr IG[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Two influenza B virus lineages, B/Victoria and B/Yamagata, cocirculate in the human population. While the lineages are serologically distinct, cross-reactive responses to both lineages have been detected. Viral interference describes the situation whereby infection with one virus limits infection and replication of a second virus. We investigated the potential for viral interference between the influenza B virus lineages.
[h=4]Methods:[/h] Ferrets were infected and then challenged 3, 10, or 28 days later with pairs of influenza B/Victoria and B/Yamagata viruses.
[h=4]Results:[/h] Viral interference occurred at challenge intervals of 3 and 10 days and occasionally at 28 days. At the longer interval, shedding of challenge virus was reduced, and this correlated with cross-reactive interferon γ responses from lymph nodes from virus-infected animals. Viruses from both lineages could prevent or significantly limit subsequent infection with a virus from the other lineage. Coinfections were rare, indicating the potential for reassortment between lineages is limited.
[h=4]Conclusions:[/h] These data suggest that innate and cross-reactive immunity mediate viral interference and that this may contribute to the dominance of a specific influenza B virus lineage in any given influenza season. Furthermore, infection with one influenza B virus lineage may be beneficial in protecting against subsequent infection with either influenza B virus lineage.
[h=4]KEYWORDS:[/h] Viral interference; cross-protection; dominance; ferret; influenza; influenza B; lineage
PMID: 29325138 DOI: 10.1093/infdis/jix509