tetano
Editor, Senior Moderator
J Infect Dis. 2019 Feb 5. doi: 10.1093/infdis/jiz046. [Epub ahead of print]
[h=1]Evidence for cross-protection to subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014.[/h] Chen IM[SUP]1,[/SUP][SUP]2[/SUP], Loh JP[SUP]3[/SUP], Chuah CXP[SUP]1[/SUP], Gao QHC[SUP]4[/SUP], Sun Y[SUP]1,[/SUP][SUP]5[/SUP], Ng SH[SUP]3[/SUP], Koh WV[SUP]3[/SUP], Goh EH[SUP]1[/SUP], Zhao X[SUP]1[/SUP], Tambyah PA[SUP]6[/SUP], Cook AR[SUP]1[/SUP], Chng J[SUP]4[/SUP], Pang J[SUP]1,[/SUP][SUP]7[/SUP], Tan BH[SUP]3[/SUP], Lee VJ[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Few studies have studied relative cross-protection between different groups of viruses through studies of sequential infections in humans. We aimed to investigate presence of short-lived relative cross-protection between specific prior viral infections and subsequent febrile respiratory illness (FRI).
[h=4]Methods:[/h] Basic Military Training (BMT) intakes between December 2009 and December 2014 were recruited, with the first FRI as the entry point. ResPlex II assays and real-time PCR assays were used to detect viral pathogens in the samples collected, followed by survival analyses to determine if infection with particular viruses conferred short-lived relative cross-protection against FRI.
[h=4]Results:[/h] Prior infection by adenovirus (Hazard ratio (HR) 0.24, 95% confidence intervals (CI) 0.14 - 0.44) or influenza virus infections (HR 0.52, 95% CI 0.38 - 0.73) conferred relative protection against subsequent FRI. Results were statistically significant at p<0.001 even after adjusting for the FRI experience by time from enlistment. Adenovirus-positive FRI episodes tended to confer protection against subsequent infection by adenovirus, coronavirus, entero/rhinovirus and influenza virus infections (p-values from 0.062 to 0.093), while influenza-positive FRI episodes tended confer protection against adenovirus (p=0.044) and influenza virus infections (p=0.081).
[h=4]Conclusion:[/h] Prior adenovirus and influenza virus infections conferred cross-protective effects to subsequent FRI episodes relative to other circulating viruses.
PMID: 30722024 DOI: 10.1093/infdis/jiz046
[h=1]Evidence for cross-protection to subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014.[/h] Chen IM[SUP]1,[/SUP][SUP]2[/SUP], Loh JP[SUP]3[/SUP], Chuah CXP[SUP]1[/SUP], Gao QHC[SUP]4[/SUP], Sun Y[SUP]1,[/SUP][SUP]5[/SUP], Ng SH[SUP]3[/SUP], Koh WV[SUP]3[/SUP], Goh EH[SUP]1[/SUP], Zhao X[SUP]1[/SUP], Tambyah PA[SUP]6[/SUP], Cook AR[SUP]1[/SUP], Chng J[SUP]4[/SUP], Pang J[SUP]1,[/SUP][SUP]7[/SUP], Tan BH[SUP]3[/SUP], Lee VJ[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Few studies have studied relative cross-protection between different groups of viruses through studies of sequential infections in humans. We aimed to investigate presence of short-lived relative cross-protection between specific prior viral infections and subsequent febrile respiratory illness (FRI).
[h=4]Methods:[/h] Basic Military Training (BMT) intakes between December 2009 and December 2014 were recruited, with the first FRI as the entry point. ResPlex II assays and real-time PCR assays were used to detect viral pathogens in the samples collected, followed by survival analyses to determine if infection with particular viruses conferred short-lived relative cross-protection against FRI.
[h=4]Results:[/h] Prior infection by adenovirus (Hazard ratio (HR) 0.24, 95% confidence intervals (CI) 0.14 - 0.44) or influenza virus infections (HR 0.52, 95% CI 0.38 - 0.73) conferred relative protection against subsequent FRI. Results were statistically significant at p<0.001 even after adjusting for the FRI experience by time from enlistment. Adenovirus-positive FRI episodes tended to confer protection against subsequent infection by adenovirus, coronavirus, entero/rhinovirus and influenza virus infections (p-values from 0.062 to 0.093), while influenza-positive FRI episodes tended confer protection against adenovirus (p=0.044) and influenza virus infections (p=0.081).
[h=4]Conclusion:[/h] Prior adenovirus and influenza virus infections conferred cross-protective effects to subsequent FRI episodes relative to other circulating viruses.
PMID: 30722024 DOI: 10.1093/infdis/jiz046