tetano
Editor, Senior Moderator
J Korean Med Sci. 2019 Dec 2;34(46):e279. doi: 10.3346/jkms.2019.34.e279. [h=1]Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6-35 Months.[/h]
Lee JH[SUP]1[/SUP], Cho HK[SUP]2[/SUP], Kim KH[SUP]3[/SUP], Lee J[SUP]4[/SUP], Kim YJ[SUP]5[/SUP], Eun BW[SUP]6[/SUP], Kim NH[SUP]7[/SUP], Kim DH[SUP]8[/SUP], Jo DS[SUP]9[/SUP], Kim HM[SUP]10[/SUP], Kim YK[SUP]11[/SUP].
[h=3]Author information[/h] 1 Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. 2 Department of Pediatrics, Gachon University College of Medicine, Incheon, Korea. 3 Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea. 4 Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 5 Department of Pediatrics, School of Medicine, Sungkyunkwan University, Seoul, Korea. 6 Department of Pediatrics, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea. 7 Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea. 8 Department of Pediatrics, Korea Institute of Radiological Medical Sciences, Seoul, Korea. 9 Department of Pediatrics, Chonbuk National University Children's Hospital, Jeonju, Korea. 10 Department of Pediatrics, Yonsei University, Wonju College of Medicine, Wonju, Korea. 11 Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. byelhana@korea.ac.kr.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at 6 months after influenza vaccination according to influenza virus strains, vaccine type, antigen dose, and primed status in children aged 6 to 35 months.
[h=4]METHODS:[/h] A total 124 healthy children aged 6 to 35 months were enrolled from September to December 2016 at 10 hospitals in Korea and randomly assigned to either a full dose of quadrivalent influenza vaccine or a half dose of trivalent influenza vaccine with Victoria B strain group. Hemagglutination inhibition antibody titers (that measure the seroprotection rates) were assessed for the recommended influenza strains at 6 months post vaccination.
[h=4]RESULTS:[/h] The seroprotection rates at 6 months for strains A (H1N1), A (H3N2), B/Yamagata, and B/Victoria were 88.7%, 97.4%, 36.6%, and 27.6%, respectively. The seroprotection rates for A (H1N1), A (H3N2) and B (Victoria) were 91.4%, 98.7% and 27.5% in a full dose of quadrivalent vaccine vs. 83.7%, 94.6% and 27.9% in a half dose trivalent vaccine, respectively. The seroprotection rate for the B (Yamagata) strain was 23.8% in the quadrivalent group and 14.0% in the trivalent group.
[h=4]CONCLUSION:[/h] Persistence of antibodies at 6 months was more favorable against the influenza A strains than against the B strains. Persistence of antibodies to additional B strain at 6 months was superior in the quadrivalent vaccine group. The immunity of primed children with different B strains was not superior to that of the unprimed group with another B strain.
? 2019 The Korean Academy of Medical Sciences.
[h=4]KEYWORDS:[/h] Children; Hemagglutination; Immunity; Quadrivalent Influenza Vaccine; Trivalent Influenza Vaccine
PMID: 31779056 DOI: 10.3346/jkms.2019.34.e279
Lee JH[SUP]1[/SUP], Cho HK[SUP]2[/SUP], Kim KH[SUP]3[/SUP], Lee J[SUP]4[/SUP], Kim YJ[SUP]5[/SUP], Eun BW[SUP]6[/SUP], Kim NH[SUP]7[/SUP], Kim DH[SUP]8[/SUP], Jo DS[SUP]9[/SUP], Kim HM[SUP]10[/SUP], Kim YK[SUP]11[/SUP].
[h=3]Author information[/h] 1 Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. 2 Department of Pediatrics, Gachon University College of Medicine, Incheon, Korea. 3 Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea. 4 Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 5 Department of Pediatrics, School of Medicine, Sungkyunkwan University, Seoul, Korea. 6 Department of Pediatrics, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea. 7 Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea. 8 Department of Pediatrics, Korea Institute of Radiological Medical Sciences, Seoul, Korea. 9 Department of Pediatrics, Chonbuk National University Children's Hospital, Jeonju, Korea. 10 Department of Pediatrics, Yonsei University, Wonju College of Medicine, Wonju, Korea. 11 Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. byelhana@korea.ac.kr.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at 6 months after influenza vaccination according to influenza virus strains, vaccine type, antigen dose, and primed status in children aged 6 to 35 months.
[h=4]METHODS:[/h] A total 124 healthy children aged 6 to 35 months were enrolled from September to December 2016 at 10 hospitals in Korea and randomly assigned to either a full dose of quadrivalent influenza vaccine or a half dose of trivalent influenza vaccine with Victoria B strain group. Hemagglutination inhibition antibody titers (that measure the seroprotection rates) were assessed for the recommended influenza strains at 6 months post vaccination.
[h=4]RESULTS:[/h] The seroprotection rates at 6 months for strains A (H1N1), A (H3N2), B/Yamagata, and B/Victoria were 88.7%, 97.4%, 36.6%, and 27.6%, respectively. The seroprotection rates for A (H1N1), A (H3N2) and B (Victoria) were 91.4%, 98.7% and 27.5% in a full dose of quadrivalent vaccine vs. 83.7%, 94.6% and 27.9% in a half dose trivalent vaccine, respectively. The seroprotection rate for the B (Yamagata) strain was 23.8% in the quadrivalent group and 14.0% in the trivalent group.
[h=4]CONCLUSION:[/h] Persistence of antibodies at 6 months was more favorable against the influenza A strains than against the B strains. Persistence of antibodies to additional B strain at 6 months was superior in the quadrivalent vaccine group. The immunity of primed children with different B strains was not superior to that of the unprimed group with another B strain.
? 2019 The Korean Academy of Medical Sciences.
[h=4]KEYWORDS:[/h] Children; Hemagglutination; Immunity; Quadrivalent Influenza Vaccine; Trivalent Influenza Vaccine
PMID: 31779056 DOI: 10.3346/jkms.2019.34.e279