tetano
Editor, Senior Moderator
Cell Immunol. 2016 Sep 7. pii: S0008-8749(16)30094-6. doi: 10.1016/j.cellimm.2016.09.005. [Epub ahead of print]
[h=1]Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity.[/h] Otani N[SUP]1[/SUP], Shima M[SUP]2[/SUP], Ueda T[SUP]3[/SUP], Ichiki K[SUP]3[/SUP], Nakajima K[SUP]3[/SUP], Takesue Y[SUP]3[/SUP], Okuno T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The immunological effect of influenza vaccines cannot be evaluated accurately using an antibody titer. Therefore, we used a new method that measures cell-mediated immunity to investigate changes in the amount of interferon-gamma (IFN-γ) produced after vaccination in response to the vaccine antigen. The study was conducted during the 2014-2015 influenza season in 23 adults, using a vaccine that contained three types of antigen. The IFN-γ level increased by at least 1.5 times in 65% (15/23) of cases in response to the H1N1 antigen, in 57% (13/23) of cases in response to the H3N2 antigen, and in 57% (13/23) of cases in response to the B antigen. During the study period, 4 subjects developed type A influenza. Our data showed that the IFN-γ level did not increase by 1.5 times in these subjects. We propose that the efficacy of influenza vaccines may be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine.
Copyright ? 2016 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Antigen; Cell-mediated immunity; Humoral immunity; Influenza; Interferon-gamma; Vaccine
PMID: 27665371 DOI: 10.1016/j.cellimm.2016.09.005
[PubMed - as supplied by publisher]
[h=1]Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity.[/h] Otani N[SUP]1[/SUP], Shima M[SUP]2[/SUP], Ueda T[SUP]3[/SUP], Ichiki K[SUP]3[/SUP], Nakajima K[SUP]3[/SUP], Takesue Y[SUP]3[/SUP], Okuno T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The immunological effect of influenza vaccines cannot be evaluated accurately using an antibody titer. Therefore, we used a new method that measures cell-mediated immunity to investigate changes in the amount of interferon-gamma (IFN-γ) produced after vaccination in response to the vaccine antigen. The study was conducted during the 2014-2015 influenza season in 23 adults, using a vaccine that contained three types of antigen. The IFN-γ level increased by at least 1.5 times in 65% (15/23) of cases in response to the H1N1 antigen, in 57% (13/23) of cases in response to the H3N2 antigen, and in 57% (13/23) of cases in response to the B antigen. During the study period, 4 subjects developed type A influenza. Our data showed that the IFN-γ level did not increase by 1.5 times in these subjects. We propose that the efficacy of influenza vaccines may be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine.
Copyright ? 2016 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Antigen; Cell-mediated immunity; Humoral immunity; Influenza; Interferon-gamma; Vaccine
PMID: 27665371 DOI: 10.1016/j.cellimm.2016.09.005
[PubMed - as supplied by publisher]