tetano
Editor, Senior Moderator
J Gen Virol. 2014 Jan 13. doi: 10.1099/vir.0.058636-0. [Epub ahead of print]
Evaluation of heterosubtypic cross-protection against highly pathogenic H5N1 by active infection with human seasonal influenza A virus or trivalent inactivated vaccine immunization in ferret models.
Park SJ, Kim EH, Pascua PN, Kwon HI, Lim GJ, Decano A, Kim SM, Song MK, Shin EC, Choi YK.
Author information
Abstract
The threat of highly pathogenic avian influenza (HPAI) H5N1 viruses to cause the next pandemic remains a major concern. Here, we evaluated the cross-protection induced by natural infection of human seasonal influenza strains or immunization with trivalent inactivated influenza vaccine (TIV) against HPAI H5N1 (A/Vietnam/1203/2004) virus in ferrets. Groups were treated with phosphate buffered saline (group A), infected with H1N1 (group B) or H3N2 (group C) virus, or immunized with TIV (group D). Twelve weeks after the last treatment, serological assays revealed that groups B and C sustained moderate immunogenicity against homologous viruses but not D; cross-reactivity against the H5N1 virus was not detected in any group. Following challenge with A/Vietnam/1203/2004(H5N1) virus, only groups B and C exhibited attenuated viral loads leading to 100% survival. Our data suggest that natural infection with human seasonal strains could potentially provide better heterosubtypic protection against HPAI H5N1 virus infection compared to TIV immunization.
KEYWORDS:
HPAI H5N1, influenza vaccine, natural infection, seasonal influenza virus
PMID:
24421115
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24421115
Evaluation of heterosubtypic cross-protection against highly pathogenic H5N1 by active infection with human seasonal influenza A virus or trivalent inactivated vaccine immunization in ferret models.
Park SJ, Kim EH, Pascua PN, Kwon HI, Lim GJ, Decano A, Kim SM, Song MK, Shin EC, Choi YK.
Author information
Abstract
The threat of highly pathogenic avian influenza (HPAI) H5N1 viruses to cause the next pandemic remains a major concern. Here, we evaluated the cross-protection induced by natural infection of human seasonal influenza strains or immunization with trivalent inactivated influenza vaccine (TIV) against HPAI H5N1 (A/Vietnam/1203/2004) virus in ferrets. Groups were treated with phosphate buffered saline (group A), infected with H1N1 (group B) or H3N2 (group C) virus, or immunized with TIV (group D). Twelve weeks after the last treatment, serological assays revealed that groups B and C sustained moderate immunogenicity against homologous viruses but not D; cross-reactivity against the H5N1 virus was not detected in any group. Following challenge with A/Vietnam/1203/2004(H5N1) virus, only groups B and C exhibited attenuated viral loads leading to 100% survival. Our data suggest that natural infection with human seasonal strains could potentially provide better heterosubtypic protection against HPAI H5N1 virus infection compared to TIV immunization.
KEYWORDS:
HPAI H5N1, influenza vaccine, natural infection, seasonal influenza virus
PMID:
24421115
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24421115