tetano
Editor, Senior Moderator
Eurosurveillance, Volume 20, Issue 39, 01 October 2015
Surveillance and outbreak report
Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15
RG Pebody [SUP]1[/SUP] , HK Green [SUP]1[/SUP] , N Andrews [SUP]1[/SUP] , NL Boddington [SUP]1[/SUP] , H Zhao [SUP]1[/SUP] , I Yonova [SUP]2[/SUP] [SUP]3[/SUP] , J Ellis [SUP]1[/SUP] , S Steinberger [SUP]1[/SUP] , M Donati [SUP]1[/SUP] , AJ Elliot [SUP]1[/SUP] , HE Hughes [SUP]1[/SUP] , S Pathirannehelage [SUP]2[/SUP] [SUP]3[/SUP] , D Mullett [SUP]2[/SUP] [SUP]3[/SUP] , GE Smith [SUP]1[/SUP] , S de Lusignan [SUP]2[/SUP] [SUP]3[/SUP] , M Zambon [SUP]1[/SUP]
+ Author affiliations
1. Public Health England (PHE), United Kingdom
2. Royal College of General Practitioners Research and Surveillance Unit, Birmingham, United Kingdom
3. University of Surrey, Guildford, United Kingdom
Correspondence: Richard G Pebody (richard.pebody@phe.gov.uk)
Citation style for this article: Pebody RG, Green HK, Andrews N, Boddington NL, Zhao H, Yonova I, Ellis J, Steinberger S, Donati M, Elliot AJ, Hughes HE, Pathirannehelage S, Mullett D, Smith GE, de Lusignan S, Zambon M. Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15. Euro Surveill. 2015;20(39)
ii=30029. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2015.20.39.30029
Received:16 June 2015; Accepted:09 September 2015
[h=4][/h]
The 2014/15 influenza season was the second season of roll-out of a live attenuated influenza vaccine (LAIV) programme for healthy children in England. During this season, besides offering LAIV to all two to four year olds, several areas piloted vaccination of primary (4?11 years) and secondary (11?13 years) age children. Influenza A(H3N2) circulated, with strains genetically and antigenically distinct from the 2014/15 A(H3N2) vaccine strain, followed by a drifted B strain. We assessed the overall and indirect impact of vaccinating school age children, comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot to non-pilot areas. Uptake levels were 56.8% and 49.8% in primary and secondary school pilot areas respectively. In primary school age pilot areas, cumulative primary care influenza-like consultation, emergency department respiratory attendance, respiratory swab positivity, hospitalisation and excess respiratory mortality were consistently lower in targeted and non-targeted age groups, though less for adults and more severe end-points, compared with non-pilot areas. There was no significant reduction for excess all-cause mortality. Little impact was seen in secondary school age pilot only areas compared with non-pilot areas. Vaccination of healthy primary school age children resulted in population-level impact despite circulation of drifted A and B influenza strains.
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21256
Surveillance and outbreak report
Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15
RG Pebody [SUP]1[/SUP] , HK Green [SUP]1[/SUP] , N Andrews [SUP]1[/SUP] , NL Boddington [SUP]1[/SUP] , H Zhao [SUP]1[/SUP] , I Yonova [SUP]2[/SUP] [SUP]3[/SUP] , J Ellis [SUP]1[/SUP] , S Steinberger [SUP]1[/SUP] , M Donati [SUP]1[/SUP] , AJ Elliot [SUP]1[/SUP] , HE Hughes [SUP]1[/SUP] , S Pathirannehelage [SUP]2[/SUP] [SUP]3[/SUP] , D Mullett [SUP]2[/SUP] [SUP]3[/SUP] , GE Smith [SUP]1[/SUP] , S de Lusignan [SUP]2[/SUP] [SUP]3[/SUP] , M Zambon [SUP]1[/SUP]
+ Author affiliations
1. Public Health England (PHE), United Kingdom
2. Royal College of General Practitioners Research and Surveillance Unit, Birmingham, United Kingdom
3. University of Surrey, Guildford, United Kingdom
Correspondence: Richard G Pebody (richard.pebody@phe.gov.uk)
Citation style for this article: Pebody RG, Green HK, Andrews N, Boddington NL, Zhao H, Yonova I, Ellis J, Steinberger S, Donati M, Elliot AJ, Hughes HE, Pathirannehelage S, Mullett D, Smith GE, de Lusignan S, Zambon M. Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15. Euro Surveill. 2015;20(39)
ii=30029. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2015.20.39.30029Received:16 June 2015; Accepted:09 September 2015
[h=4][/h]
The 2014/15 influenza season was the second season of roll-out of a live attenuated influenza vaccine (LAIV) programme for healthy children in England. During this season, besides offering LAIV to all two to four year olds, several areas piloted vaccination of primary (4?11 years) and secondary (11?13 years) age children. Influenza A(H3N2) circulated, with strains genetically and antigenically distinct from the 2014/15 A(H3N2) vaccine strain, followed by a drifted B strain. We assessed the overall and indirect impact of vaccinating school age children, comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot to non-pilot areas. Uptake levels were 56.8% and 49.8% in primary and secondary school pilot areas respectively. In primary school age pilot areas, cumulative primary care influenza-like consultation, emergency department respiratory attendance, respiratory swab positivity, hospitalisation and excess respiratory mortality were consistently lower in targeted and non-targeted age groups, though less for adults and more severe end-points, compared with non-pilot areas. There was no significant reduction for excess all-cause mortality. Little impact was seen in secondary school age pilot only areas compared with non-pilot areas. Vaccination of healthy primary school age children resulted in population-level impact despite circulation of drifted A and B influenza strains.
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21256