Eurosurv. Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Ger

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• Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020
  
  
  
• Claudia Santos-H?vener[SUP]1,2[/SUP] , Hannelore K Neuhauser[SUP]1,2[/SUP] , Angelika Schaffrath Rosario[SUP]1[/SUP] , Markus Busch[SUP]1[/SUP] , Martin Schlaud[SUP]1[/SUP] , Robert Hoffmann[SUP]1[/SUP] , Antje G??wald[SUP]1[/SUP] , Carmen Koschollek[SUP]1[/SUP] , Jens Hoebel[SUP]1[/SUP] , Jennifer Allen[SUP]1[/SUP] , Antje Haack-Erdmann[SUP]3[/SUP] , Stefan Brockmann[SUP]4[/SUP] , Thomas Ziese[SUP]1[/SUP] , Andreas Nitsche[SUP]1[/SUP] , Janine Michel[SUP]1[/SUP] , Sebastian Haller[SUP]1[/SUP] , Hendrik Wilking[SUP]1[/SUP] , Osamah Hamouda[SUP]1[/SUP] , Victor M Corman[SUP]5,6[/SUP] , Christian Drosten[SUP]5,6[/SUP] , Lars Schaade[SUP]1[/SUP] , Lothar H Wieler[SUP]1[/SUP] , CoMoLo Study Group[SUP]7[/SUP] , Thomas Lampert[SUP]1[/SUP]

After a large church concert on 1 March 2020 and a first detected infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on 9 March, the southern German community of Kupferzell in the federal state Baden-W?rttemberg faced a steep increase of SARS-CoV-2 infections. Investigations of the local health authorities showed increasing evidence of community spreading in a complex and chronologically dense pattern of travel returnees who attended a choir and trombone church concert. Wide-reaching infection prevention and local control measures were implemented starting in the week of the first case detection, followed by additional measures such as a ban on gatherings in the federal state starting mid-March. The number of SARS-CoV-2 infections peaked in March but waned in April, and there were only three cases in May (Figure). There were three deaths, aged 59, 81 and 91 years. The cumulative incidence of 1,760 per 100,000 in Kupferzell by the end of April was, at the time of the study, one of the highest in Germany. The Robert Koch Institute (RKI) set out to analyse the SARS-CoV-2 seroprevalence in a random sample of this community from 20 May to 9 June.

Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4–14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% na?ve adults are still at high COVID-19 risk.

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https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.47.2001752#html_fulltext