Eurosurv. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

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• SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
  
  
• Sheila F Lumley[SUP]1,2,3[/SUP] , David W Eyre[SUP]1,2,3,4[/SUP] , Anna L McNaughton[SUP]1,3[/SUP] , Alison Howarth[SUP]5[/SUP] , Sarah Hoosdally[SUP]5[/SUP] , Stephanie B Hatch[SUP]6[/SUP] , James Kavanagh[SUP]5[/SUP] , Kevin K Chau[SUP]5[/SUP] , Louise O Downs[SUP]2[/SUP] , Stuart Cox[SUP]7[/SUP] , Laura Dunn[SUP]2[/SUP] , Anita Justice[SUP]2[/SUP] , Susan Wareing[SUP]2[/SUP] , Kate Dingle[SUP]5[/SUP] , Justine Rudkin[SUP]4[/SUP] , Kathryn Auckland[SUP]5[/SUP] , Alexander Fyfe[SUP]8[/SUP] , Jai Bolton[SUP]8[/SUP] , Robert Paton[SUP]8[/SUP] , Alexander J Mentzer[SUP]2,5[/SUP] , Katie Jeffery[SUP]2[/SUP] , Monique I Andersson[SUP]2[/SUP] , Tim James[SUP]7[/SUP] , Tim E A Peto[SUP]2,5[/SUP] , Brian D Marsden[SUP]9,10,11[/SUP] , Gavin Screaton[SUP]12[/SUP] , Richard J Cornall[SUP]12[/SUP] , Paul Klenerman[SUP]1,2,5[/SUP] , Daniel Ebner[SUP]6[/SUP] , David I Stuart[SUP]6,10,11[/SUP] , Derrick W Crook[SUP]2,5[/SUP] , Nicole Stoesser[SUP]2,5[/SUP] , Stephen H Kennedy[SUP]13[/SUP] , Craig Thompson[SUP]8[/SUP] , Sunetra Gupta[SUP]8[/SUP] , Philippa C Matthews[SUP]1,2,3,5[/SUP]

During the first peak of the coronavirus disease (COVID-19) pandemic in the United Kingdom (UK) between April and June 2020, we set out to generate a benchmark estimate of antenatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in a population of pregnant women in the Oxford area. We also evaluated an IgG enzyme-linked immunosorbent assay (ELISA) head-to-head with a pseudotyped virus neutralisation test in this group, and investigated the extent to which routine antenatal testing for SARS-CoV-2 IgG antibody could inform population surveillance efforts.

full article

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.41.2001721#html_fulltext