tetano
Editor, Senior Moderator
Eurosurveillance, Volume 21, Issue 24, 16 June 2016
Rapid communication
Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016
E Takashita [SUP]1[/SUP] , S Fujisaki [SUP]1[/SUP] , M Shirakura [SUP]1[/SUP] , K Nakamura [SUP]1[/SUP] , N Kishida [SUP]1[/SUP] , T Kuwahara [SUP]1[/SUP] , Y Shimazu [SUP]2[/SUP] , T Shimomura [SUP]3[/SUP] , S Watanabe [SUP]1[/SUP] , T Odagiri [SUP]1[/SUP] , The Influenza Virus Surveillance Group of Japan [SUP]4[/SUP]
+ Author affiliations
1. Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
2. Center for Public Health and Environment, Hiroshima Prefectural Technology Research Institute, Hiroshima, Japan
3. Hiroshima Nishi Medical Center, Hiroshima, Japan
4. The members of the group are listed at the end of the article
Correspondence: Takato Odagiri (todagiri@nih.go.jp
Citation style for this article: Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Watanabe S, Odagiri T, The Influenza Virus Surveillance Group of Japan. Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016. Euro Surveill. 2016;21(24)
ii=30258. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.24.30258
Received:20 May 2016; Accepted:16 June 2016
[h=4][/h]
An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.
full article
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=22503
Rapid communication
Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016
E Takashita [SUP]1[/SUP] , S Fujisaki [SUP]1[/SUP] , M Shirakura [SUP]1[/SUP] , K Nakamura [SUP]1[/SUP] , N Kishida [SUP]1[/SUP] , T Kuwahara [SUP]1[/SUP] , Y Shimazu [SUP]2[/SUP] , T Shimomura [SUP]3[/SUP] , S Watanabe [SUP]1[/SUP] , T Odagiri [SUP]1[/SUP] , The Influenza Virus Surveillance Group of Japan [SUP]4[/SUP]
+ Author affiliations
1. Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
2. Center for Public Health and Environment, Hiroshima Prefectural Technology Research Institute, Hiroshima, Japan
3. Hiroshima Nishi Medical Center, Hiroshima, Japan
4. The members of the group are listed at the end of the article
Correspondence: Takato Odagiri (todagiri@nih.go.jp
Citation style for this article: Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Watanabe S, Odagiri T, The Influenza Virus Surveillance Group of Japan. Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016. Euro Surveill. 2016;21(24)
ii=30258. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.24.30258Received:20 May 2016; Accepted:16 June 2016
[h=4][/h]
An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.
full article
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=22503