Eurosurv. Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, Marc

[tetano]

• Rebecca Amati[SUP]1,*[/SUP] , Anja Frei[SUP]2,*[/SUP] , Marco Kaufmann[SUP]2[/SUP] , Serena Sabatini[SUP]1[/SUP] , Céline Pellaton[SUP]3[/SUP] , Jan Fehr[SUP]2[/SUP] , Emiliano Albanese[SUP]1,**[/SUP] , Milo A Puhan[SUP]2,**[/SUP] , on behalf of the Corona Immunitas Research Group[SUP]4[/SUP]

Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8–98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.




https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.31.2200561#html_fulltext