Eurosurv. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

[tetano]

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

• Kathy Leung[SUP]1,2[/SUP], Marcus HH Shum[SUP]1,2,3,4[/SUP] , Gabriel M Leung[SUP]1,2[/SUP], Tommy TY Lam[SUP]1,2,3,4[/SUP], Joseph T Wu[SUP]1,2[/SUP]

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

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https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.26.1.2002106#html_fulltext