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Eurosurv. Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024

M

Mary Wilson

Well-known member
09/Jan/2025​

https://doi.org/10.2807/1560-7917.ES.2025.30.1.2400839​

Sun Wanying, Choy Ka Tim, Cheng Ka Man, Brackman Christopher J, Cheng Samuel MS, Sit Thomas HC, Tse Anne CN, Sims Leslie D, Gu Haogao, Tang Amy WY, Wong Andrew NC, Tsang Andrew TL, Koo Joe CT, Luk Leo LH, Yen Hui-Ling, Peris Malik, Poon Leo LM.​​

Abstract​

We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021–2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.​

https://www.eurosurveillance.org/docserver/fulltext/eurosurveillance/30/1/eurosurv-30-1-4.pdf?expires=1736485078&id=id&accname=guest&check sum=D64EB23FDFD8C1196DC58AC46FA1BE06
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Or :): https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.1.2400839#html_fulltext
 
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