Eurosurv. Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the commun

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• François Blanquart[SUP]1,2[/SUP] , Clémence Abad[SUP]3[/SUP] , Joëvin Ambroise[SUP]4[/SUP] , Mathieu Bernard[SUP]5[/SUP] , Gina Cosentino[SUP]4,6[/SUP] , Jean-Marc Giannoli[SUP]7[/SUP] , Florence Débarre[SUP]8[/SUP]

We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10[SUP]−6[/SUP]). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10[SUP]−6[/SUP]).

full article

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.37.2100824#html_fulltext