tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2019 Feb 18. pii: S1198-743X(19)30058-8. doi: 10.1016/j.cmi.2019.02.011. [Epub ahead of print]
[h=1]European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?[/h] Nielsen J[SUP]1[/SUP], Vestergaard LS[SUP]2[/SUP], Richter L[SUP]3[/SUP], Schmid D[SUP]3[/SUP], Bustos N[SUP]4[/SUP], Asikainen T[SUP]4[/SUP], Trebbien R[SUP]2[/SUP], Denissov G[SUP]5[/SUP], Innos K[SUP]5[/SUP], Virtanen MJ[SUP]6[/SUP], Fouillet A[SUP]7[/SUP], Lytras T[SUP]8[/SUP], Gkolfinopoulou K[SUP]8[/SUP], Heiden MA[SUP]9[/SUP], Grabenhenrich L[SUP]9[/SUP], Uphoff H[SUP]10[/SUP], Paldy A[SUP]11[/SUP], Bobvos J[SUP]12[/SUP], Domegan L[SUP]13[/SUP], O'Donnell J[SUP]13[/SUP], Scortichini M[SUP]14[/SUP], de Martino A[SUP]15[/SUP], Mossong J[SUP]16[/SUP], England K[SUP]17[/SUP], Melillo J[SUP]18[/SUP], van Asten L[SUP]19[/SUP], Lange MM[SUP]19[/SUP], T?nnessen R[SUP]20[/SUP], White RA[SUP]20[/SUP], da Silva SP[SUP]21[/SUP], Rodrigues AP[SUP]21[/SUP], Larrauri A[SUP]22[/SUP], Mazagatos C[SUP]22[/SUP], Farah A[SUP]23[/SUP], Carnahan AD[SUP]23[/SUP], Junker C[SUP]24[/SUP], Sinnathamby M[SUP]25[/SUP], Pebody RG[SUP]25[/SUP], Andrews N[SUP]25[/SUP], Reynolds A[SUP]26[/SUP], McMenamin J[SUP]26[/SUP], Brown CS[SUP]27[/SUP], Adlhoch C[SUP]28[/SUP], Penttinen P[SUP]28[/SUP], M?lbak K[SUP]29[/SUP], Krause TG[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe.
[h=4]METHODS:[/h] Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excl. Russia and the Turkey part of European, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures.
[h=4]RESULTS:[/h] Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths.
[h=4]CONCLUSIONS:[/h] The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] B/Yamagata; EuroMOMO; FluMOMO; Mortality; influenza
PMID: 30790685 DOI: 10.1016/j.cmi.2019.02.011
[h=1]European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?[/h] Nielsen J[SUP]1[/SUP], Vestergaard LS[SUP]2[/SUP], Richter L[SUP]3[/SUP], Schmid D[SUP]3[/SUP], Bustos N[SUP]4[/SUP], Asikainen T[SUP]4[/SUP], Trebbien R[SUP]2[/SUP], Denissov G[SUP]5[/SUP], Innos K[SUP]5[/SUP], Virtanen MJ[SUP]6[/SUP], Fouillet A[SUP]7[/SUP], Lytras T[SUP]8[/SUP], Gkolfinopoulou K[SUP]8[/SUP], Heiden MA[SUP]9[/SUP], Grabenhenrich L[SUP]9[/SUP], Uphoff H[SUP]10[/SUP], Paldy A[SUP]11[/SUP], Bobvos J[SUP]12[/SUP], Domegan L[SUP]13[/SUP], O'Donnell J[SUP]13[/SUP], Scortichini M[SUP]14[/SUP], de Martino A[SUP]15[/SUP], Mossong J[SUP]16[/SUP], England K[SUP]17[/SUP], Melillo J[SUP]18[/SUP], van Asten L[SUP]19[/SUP], Lange MM[SUP]19[/SUP], T?nnessen R[SUP]20[/SUP], White RA[SUP]20[/SUP], da Silva SP[SUP]21[/SUP], Rodrigues AP[SUP]21[/SUP], Larrauri A[SUP]22[/SUP], Mazagatos C[SUP]22[/SUP], Farah A[SUP]23[/SUP], Carnahan AD[SUP]23[/SUP], Junker C[SUP]24[/SUP], Sinnathamby M[SUP]25[/SUP], Pebody RG[SUP]25[/SUP], Andrews N[SUP]25[/SUP], Reynolds A[SUP]26[/SUP], McMenamin J[SUP]26[/SUP], Brown CS[SUP]27[/SUP], Adlhoch C[SUP]28[/SUP], Penttinen P[SUP]28[/SUP], M?lbak K[SUP]29[/SUP], Krause TG[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe.
[h=4]METHODS:[/h] Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excl. Russia and the Turkey part of European, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures.
[h=4]RESULTS:[/h] Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths.
[h=4]CONCLUSIONS:[/h] The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] B/Yamagata; EuroMOMO; FluMOMO; Mortality; influenza
PMID: 30790685 DOI: 10.1016/j.cmi.2019.02.011