Giuseppe
Emeritus
[Source: Eurosurveillance, full text: (LINK). Abstract, edited.]
Eurosurveillance, Volume 16, Issue 23, 09 June 2011
Rapid communications
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Eurosurveillance, Volume 16, Issue 23, 09 June 2011
Rapid communications
Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation
A C Hurt (
)<SUP>1</SUP>, R T Lee<SUP>2</SUP>, S K Leang<SUP>1</SUP>, L Cui<SUP>3</SUP>, Y M Deng<SUP>1</SUP>, S P Phuah<SUP>3</SUP>, N Caldwell<SUP>1</SUP>, K Freeman<SUP>4</SUP>, N Komadina<SUP>1</SUP>, D Smith<SUP>5</SUP>, D Speers<SUP>5</SUP>, A Kelso<SUP>1</SUP>, R T Lin<SUP>3</SUP>, S Maurer-Stroh<SUP>2</SUP><SUP>,3</SUP><SUP>,6</SUP>, I G Barr<SUP>1</SUP>
Citation style for this article: Hurt AC, Lee RT, Leang SK, Cui L, Deng YM, Phuah SP, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin RT, Maurer-Stroh S, Barr IG. Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation. Euro Surveill. 2011;16(23)
ii=19884. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19884
Date of submission: 26 May 2011 <HR>A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.
A C Hurt (
- World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
- Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore
- National Public Health Laboratory, Communicable Diseases Division Ministry of Health, Singapore
- Serology/Molecular Biology Department, Royal Darwin Hospital, Darwin, Australia
- PathWest Laboratory Medicine, Nedlands, Western Australia
- School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore
Citation style for this article: Hurt AC, Lee RT, Leang SK, Cui L, Deng YM, Phuah SP, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin RT, Maurer-Stroh S, Barr IG. Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation. Euro Surveill. 2011;16(23)
ii=19884. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19884 Date of submission: 26 May 2011 <HR>A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.
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