Euro Surveill. Early and unexpectedly severe start of influenza epidemic in the Czech Republic during influenza season 2012-13

[Giuseppe]

[Source: Eurosurveillance, full text: (LINK). Abstract, edited.]

Eurosurveillance, Volume 18, Issue 6, 07 February 2013

Rapid communications

Early and unexpectedly severe start of influenza epidemic in the Czech Republic during influenza season 2012-13

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J Kyncl ()<SUP>1</SUP><SUP>,2</SUP>, M Havlickova<SUP>3</SUP>, A Nagy<SUP>3</SUP>, H Jirincova<SUP>3</SUP>, I Piskova<SUP>4</SUP>

1. Department of Infectious Diseases Epidemiology, National Institute of Public Health, Prague, Czech Republic
2. Department of Epidemiology, Third Faculty of Medicine, Charles University in Prague, Czech Republic
3. National Reference Laboratory for Influenza, National Institute of Public Health, Prague, Czech Republic
4. Epidemiology Division, Department of Public Health Protection, Ministry of Health of the Czech Republic, Prague, Czech Republic

<HR>
Citation style for this article: Kyncl J, Havlickova M, Nagy A, Jirincova H, Piskova I. Early and unexpectedly severe start of influenza epidemic in the Czech Republic during influenza season 2012-13. Euro Surveill. 2013;18(6)ii=20396. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20396
Date of submission: 30 January 2013 <HR>A sudden increase in severe influenza has been registered in the Czech Republic since the end of 2012, with 264 cases requiring intensive care, including 51 deaths. Most patients had at least one risk factor. Severe influenza in patients with obesity, smoking and/or haematological disorders including haematological cancers was more frequent than in the pre-pandemic period. The seasonal influenza vaccination status of the cases indicates indirect efficiency of the current vaccine in preventing severe influenza.
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[gsgs]

Re: Euro Surveill. Early and unexpectedly severe start of influenza epidemic in the Czech Republic during influenza season 2012-13

tetano reports currently 350 ICU cases and 68 deaths


A/St.Petersburg/27/2011
A/Dnepropetrovsk/4929/2011
A/Cheboksary/IIV-92/2011
A/Minsk/1131/2011
A/Kastamonu/TR-45/2011
A/Singapore/GP4670/2010
A/Czech/146/2012
A/Czech/147/2012
http://www.eurosurveillance.org/images/dynamic/EE/V18N06/KYNCL_Fig2.jpg

http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20396

264 ICU patients, 174 H1, 76 A?, 6 H3, 1 B, 7 ? . mean age = 56 , 51 deaths
group 6 , currently predominating Europe

wrt. A/California/7/2009(H1N1) up to 12/549 amino acid changes
H141R, S188T , (S206T.(H3-numbering)

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In the current situation, it appears that there was to stop an increase in an epidemic.
Obviously, then we're close to its peak. The decrease is in most regions and in all age
groups," said the Valenta. In the 100 thousand people this week 1756 cases of disease.
The numbers acute respiratory diseases decreased compared to the previous week by
3,4 percentage points, flu by 4.3 percent.

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>A/Cheboksary/IIV-92/2011,2011/02/22,H1N1,10,1-1701,10,6
G340A,A579G,G605C,T658A,A716G,T1056C,G1171A,A1386G,G1403A,C1408T
D114N,S202T,S220T,D239G,E391K,S468N

>A/Singapore/GP4670/2010,2010/12/30,H1N1,12,1-1701,12,6
G340A,A528C,A579G,G605C,T658A,A745G,T1056C,G1158A,G1171A,A1386G,G1403A,C1408T
D114N,S202T,S220T,T249A,E391K,S468N

Ohio,Denmark Jan. 2011 UK/India-variant
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