tetano
Editor, Senior Moderator
Eur Urol. 2020 Apr 2. pii: S0302-2838(20)30205-0. doi: 10.1016/j.eururo.2020.03.030. [Epub ahead of print]
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019.
Zhang H[SUP]1[/SUP], Chen Y[SUP]2[/SUP], Yuan Q[SUP]3[/SUP], Xia QX[SUP]4[/SUP], Zeng XP[SUP]4[/SUP], Peng JT[SUP]4[/SUP], Liu J[SUP]4[/SUP], Xiao XY[SUP]4[/SUP], Jiang GS[SUP]4[/SUP], Xiao HY[SUP]4[/SUP], Xie LB[SUP]4[/SUP], Chen J[SUP]4[/SUP], Liu JL[SUP]4[/SUP], Xiao X[SUP]4[/SUP], Su H[SUP]5[/SUP], Zhang C[SUP]5[/SUP], Zhang XP[SUP]4[/SUP], Yang H[SUP]6[/SUP], Li H[SUP]4[/SUP], Wang ZD[SUP]7[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19) is a novel and lethal infectious disease, posing a threat to global health security. The number of cases has increased rapidly, but no data concerning kidney transplant (KTx) recipients infected with COVID-19 are available. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. As of March 4, 2020 NAT was negative for COVID-19 in three patients twice in succession, and their computed tomography scans showed improved images. Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy.
Copyright ? 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Clinical feature; Coronavirus disease 2019; Kidney transplant recipient
PMID:32249089DOI:10.1016/j.eururo.2020.03.030
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019.
Zhang H[SUP]1[/SUP], Chen Y[SUP]2[/SUP], Yuan Q[SUP]3[/SUP], Xia QX[SUP]4[/SUP], Zeng XP[SUP]4[/SUP], Peng JT[SUP]4[/SUP], Liu J[SUP]4[/SUP], Xiao XY[SUP]4[/SUP], Jiang GS[SUP]4[/SUP], Xiao HY[SUP]4[/SUP], Xie LB[SUP]4[/SUP], Chen J[SUP]4[/SUP], Liu JL[SUP]4[/SUP], Xiao X[SUP]4[/SUP], Su H[SUP]5[/SUP], Zhang C[SUP]5[/SUP], Zhang XP[SUP]4[/SUP], Yang H[SUP]6[/SUP], Li H[SUP]4[/SUP], Wang ZD[SUP]7[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19) is a novel and lethal infectious disease, posing a threat to global health security. The number of cases has increased rapidly, but no data concerning kidney transplant (KTx) recipients infected with COVID-19 are available. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. As of March 4, 2020 NAT was negative for COVID-19 in three patients twice in succession, and their computed tomography scans showed improved images. Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy.
Copyright ? 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Clinical feature; Coronavirus disease 2019; Kidney transplant recipient
PMID:32249089DOI:10.1016/j.eururo.2020.03.030