tetano
Editor, Senior Moderator
Eur Respir Rev
. 2023 Mar 8;32(167):220197.
doi: 10.1183/16000617.0197-2022. Print 2023 Mar 31.
Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection
Rupsha Fraser[SUP] 1 [/SUP], Aurelio Orta-Resendiz[SUP] 2 [/SUP], David Dockrell[SUP] 3 [/SUP], Michaela Müller-Trutwin[SUP] 2 [/SUP], Alexander Mazein[SUP] 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both.
. 2023 Mar 8;32(167):220197.
doi: 10.1183/16000617.0197-2022. Print 2023 Mar 31.
Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection
Rupsha Fraser[SUP] 1 [/SUP], Aurelio Orta-Resendiz[SUP] 2 [/SUP], David Dockrell[SUP] 3 [/SUP], Michaela Müller-Trutwin[SUP] 2 [/SUP], Alexander Mazein[SUP] 4 [/SUP]
Affiliations
- PMID: 36889788
- DOI: 10.1183/16000617.0197-2022
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both.