tetano
Editor, Senior Moderator
Eur Respir J
. 2021 Apr 22;2004125.
doi: 10.1183/13993003.04125-2020. Online ahead of print.
Interstitial lung disease increases susceptibility to and severity of COVID-19
Hyun Lee[SUP] 1 2 [/SUP], Hayoung Choi[SUP] 3 2 [/SUP], Bumhee Yang[SUP] 4 2 [/SUP], Sun-Kyung Lee[SUP] 1 5 [/SUP], Tai Sun Park[SUP] 1 [/SUP], Dong Won Park[SUP] 1 [/SUP], Ji-Yong Moon[SUP] 1 [/SUP], Tae-Hyung Kim[SUP] 1 [/SUP], Jang Won Sohn[SUP] 1 [/SUP], Ho Joo Yoon[SUP] 1 [/SUP], Sang-Heon Kim[SUP] 6 [/SUP]
Affiliations
Abstract
Background: There are limited data regarding the relationship between interstitial lung disease (ILD) and the natural course of coronavirus disease 2019 (COVID-19). In this study, we investigate whether patients with ILD are more susceptible to COVID-19 than those without ILD and evaluate the impact of ILD on disease severity in patients with COVID-19.
Methods: A nationwide cohort of patients with COVID-19 (n=8070) and a 1:15 age-, sex-, and residence-matched cohort (n=121 050) were constructed between January 1, 2020 and May 30, 2020 in Korea. We performed a nested case-control study to compare the proportions of patients with ILD between the COVID-19 cohort and the matched cohort. Using the COVID-19 cohort, we also evaluated the risk of severe COVID-19 in patients with ILD versus those without ILD.
Results: The proportion of patients with ILD was significantly higher in the COVID-19 cohort than in the matched cohort (0.8% versus 0.4%, p<0.001). The odds ratio [OR] of having ILD was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR=2.02, 95% confidence interval [CI]=1.54-2.61). Among patients in the COVID-19 cohort, patients with ILD were more likely to have severe COVID-19 than patients without ILD (49.3% versus 13.1%), including mortality (13.4% versus 2.8%) (all p<0.01). The risk of severe COVID-19 was significantly higher in patients with ILD than in those without ILD (adjusted OR=2.32, 95% CI=1.24-4.01).
Conclusion: The risks of COVID-19 and severe presentation were significantly higher in patients with ILD than in those without ILD.
. 2021 Apr 22;2004125.
doi: 10.1183/13993003.04125-2020. Online ahead of print.
Interstitial lung disease increases susceptibility to and severity of COVID-19
Hyun Lee[SUP] 1 2 [/SUP], Hayoung Choi[SUP] 3 2 [/SUP], Bumhee Yang[SUP] 4 2 [/SUP], Sun-Kyung Lee[SUP] 1 5 [/SUP], Tai Sun Park[SUP] 1 [/SUP], Dong Won Park[SUP] 1 [/SUP], Ji-Yong Moon[SUP] 1 [/SUP], Tae-Hyung Kim[SUP] 1 [/SUP], Jang Won Sohn[SUP] 1 [/SUP], Ho Joo Yoon[SUP] 1 [/SUP], Sang-Heon Kim[SUP] 6 [/SUP]
Affiliations
- PMID: 33888524
- DOI: 10.1183/13993003.04125-2020
Abstract
Background: There are limited data regarding the relationship between interstitial lung disease (ILD) and the natural course of coronavirus disease 2019 (COVID-19). In this study, we investigate whether patients with ILD are more susceptible to COVID-19 than those without ILD and evaluate the impact of ILD on disease severity in patients with COVID-19.
Methods: A nationwide cohort of patients with COVID-19 (n=8070) and a 1:15 age-, sex-, and residence-matched cohort (n=121 050) were constructed between January 1, 2020 and May 30, 2020 in Korea. We performed a nested case-control study to compare the proportions of patients with ILD between the COVID-19 cohort and the matched cohort. Using the COVID-19 cohort, we also evaluated the risk of severe COVID-19 in patients with ILD versus those without ILD.
Results: The proportion of patients with ILD was significantly higher in the COVID-19 cohort than in the matched cohort (0.8% versus 0.4%, p<0.001). The odds ratio [OR] of having ILD was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR=2.02, 95% confidence interval [CI]=1.54-2.61). Among patients in the COVID-19 cohort, patients with ILD were more likely to have severe COVID-19 than patients without ILD (49.3% versus 13.1%), including mortality (13.4% versus 2.8%) (all p<0.01). The risk of severe COVID-19 was significantly higher in patients with ILD than in those without ILD (adjusted OR=2.32, 95% CI=1.24-4.01).
Conclusion: The risks of COVID-19 and severe presentation were significantly higher in patients with ILD than in those without ILD.