tetano
Editor, Senior Moderator
Eur J Radiol Open
. 2023;10:100483.
doi: 10.1016/j.ejro.2023.100483. Epub 2023 Mar 3.
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans
Takuya Hino[SUP] 1 2 [/SUP], Mizuki Nishino[SUP] 1 [/SUP], Vladimir I Valtchinov[SUP] 1 [/SUP], Staci Gagne[SUP] 1 [/SUP], Elizabeth Gay[SUP] 3 [/SUP], Noriaki Wada[SUP] 1 [/SUP], Shu Chi Tseng[SUP] 1 [/SUP], Bruno Madore[SUP] 1 [/SUP], Charles R G Guttmann[SUP] 4 [/SUP], Kousei Ishigami[SUP] 2 [/SUP], Yi Li[SUP] 5 [/SUP], David C Christiani[SUP] 6 7 [/SUP], Gary M Hunninghake[SUP] 1 [/SUP], Bruce D Levy[SUP] 3 [/SUP], Kenneth M Kaye[SUP] 8 [/SUP], Hiroto Hatabu[SUP] 1 [/SUP]
Affiliations
Abstract
Purpose: To investigate the association of the maximal severity of pneumonia on CT scans obtained within 6-week of diagnosis with the subsequent development of post-COVID-19 lung abnormalities (Co-LA).
Methods: COVID-19 patients diagnosed at our hospital between March 2020 and September 2021 were studied retrospectively. The patients were included if they had (1) at least one chest CT scan available within 6-week of diagnosis; and (2) at least one follow-up chest CT scan available ≥ 6 months after diagnosis, which were evaluated by two independent radiologists. Pneumonia Severity Categories were assigned on CT at diagnosis according to the CT patterns of pneumonia and extent as: 1) no pneumonia (Estimated Extent, 0%); 2) non-extensive pneumonia (GGO and OP, <40%); and 3) extensive pneumonia (extensive OP and DAD, >40%). Co-LA on follow-up CT scans, categorized using a 3-point Co-LA Score (0, No Co-LA; 1, Indeterminate Co-LA; and 2, Co-LA).
Results: Out of 132 patients, 42 patients (32%) developed Co-LA on their follow-up CT scans 6-24 months post diagnosis. The severity of COVID-19 pneumonia was associated with Co-LA: In 47 patients with extensive pneumonia, 33 patients (70%) developed Co-LA, of whom 18 (55%) developed fibrotic Co-LA. In 52 with non-extensive pneumonia, 9 (17%) developed Co-LA: In 33 with no pneumonia, none (0%) developed Co-LA.
Conclusions: Higher severity of pneumonia at diagnosis was associated with the increased risk of development of Co-LA after 6-24 months of SARS-CoV-2 infection.
Keywords: 2019-nCoV, 2019 novel coronavirus; ARDS, acute respiratory distress syndrome; Abnormalities; COVID-19; COVID-19 pneumonia; COVID-19 related lung abnormalities; COVID-19, coronavirus disease 2019; Chest CT; Co-LA, post-COVID-19 lung abnormalities; DAD, diffuse alveolar damage; GGO, ground-glass opacity; ILA, interstitial lung abnormalities; ILD, interstitial lung disease; Lung; OP, organizing pneumonia; PE, pulmonary embolism; SARS-CoV2, severe acute respiratory syndrome coronavirus 2.
. 2023;10:100483.
doi: 10.1016/j.ejro.2023.100483. Epub 2023 Mar 3.
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans
Takuya Hino[SUP] 1 2 [/SUP], Mizuki Nishino[SUP] 1 [/SUP], Vladimir I Valtchinov[SUP] 1 [/SUP], Staci Gagne[SUP] 1 [/SUP], Elizabeth Gay[SUP] 3 [/SUP], Noriaki Wada[SUP] 1 [/SUP], Shu Chi Tseng[SUP] 1 [/SUP], Bruno Madore[SUP] 1 [/SUP], Charles R G Guttmann[SUP] 4 [/SUP], Kousei Ishigami[SUP] 2 [/SUP], Yi Li[SUP] 5 [/SUP], David C Christiani[SUP] 6 7 [/SUP], Gary M Hunninghake[SUP] 1 [/SUP], Bruce D Levy[SUP] 3 [/SUP], Kenneth M Kaye[SUP] 8 [/SUP], Hiroto Hatabu[SUP] 1 [/SUP]
Affiliations
- PMID: 36883046
- PMCID: PMC9981527
- DOI: 10.1016/j.ejro.2023.100483
Abstract
Purpose: To investigate the association of the maximal severity of pneumonia on CT scans obtained within 6-week of diagnosis with the subsequent development of post-COVID-19 lung abnormalities (Co-LA).
Methods: COVID-19 patients diagnosed at our hospital between March 2020 and September 2021 were studied retrospectively. The patients were included if they had (1) at least one chest CT scan available within 6-week of diagnosis; and (2) at least one follow-up chest CT scan available ≥ 6 months after diagnosis, which were evaluated by two independent radiologists. Pneumonia Severity Categories were assigned on CT at diagnosis according to the CT patterns of pneumonia and extent as: 1) no pneumonia (Estimated Extent, 0%); 2) non-extensive pneumonia (GGO and OP, <40%); and 3) extensive pneumonia (extensive OP and DAD, >40%). Co-LA on follow-up CT scans, categorized using a 3-point Co-LA Score (0, No Co-LA; 1, Indeterminate Co-LA; and 2, Co-LA).
Results: Out of 132 patients, 42 patients (32%) developed Co-LA on their follow-up CT scans 6-24 months post diagnosis. The severity of COVID-19 pneumonia was associated with Co-LA: In 47 patients with extensive pneumonia, 33 patients (70%) developed Co-LA, of whom 18 (55%) developed fibrotic Co-LA. In 52 with non-extensive pneumonia, 9 (17%) developed Co-LA: In 33 with no pneumonia, none (0%) developed Co-LA.
Conclusions: Higher severity of pneumonia at diagnosis was associated with the increased risk of development of Co-LA after 6-24 months of SARS-CoV-2 infection.
Keywords: 2019-nCoV, 2019 novel coronavirus; ARDS, acute respiratory distress syndrome; Abnormalities; COVID-19; COVID-19 pneumonia; COVID-19 related lung abnormalities; COVID-19, coronavirus disease 2019; Chest CT; Co-LA, post-COVID-19 lung abnormalities; DAD, diffuse alveolar damage; GGO, ground-glass opacity; ILA, interstitial lung abnormalities; ILD, interstitial lung disease; Lung; OP, organizing pneumonia; PE, pulmonary embolism; SARS-CoV2, severe acute respiratory syndrome coronavirus 2.