tetano
Editor, Senior Moderator
Eur J Radiol. 2020 Mar 25;126:108961. doi: 10.1016/j.ejrad.2020.108961. [Epub ahead of print]
Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?
Long C[SUP]1[/SUP], Xu H[SUP]2[/SUP], Shen Q[SUP]3[/SUP], Zhang X[SUP]4[/SUP], Fan B[SUP]5[/SUP], Wang C[SUP]6[/SUP], Zeng B[SUP]7[/SUP], Li Z[SUP]8[/SUP], Li X[SUP]9[/SUP], Li H[SUP]10[/SUP].
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Abstract
PURPOSE:
To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia.
METHODS:
This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated.
RESULTS:
A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%.
CONCLUSION:
rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
Coronavirus; Pneumonia; Severe Acute Respiratory Syndrome; Tomography; X-Ray Computed
PMID:32229322PMCID:PMC7102545DOI:10.1016/j.ejrad.2020.108961
Free PMC Article
Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?
Long C[SUP]1[/SUP], Xu H[SUP]2[/SUP], Shen Q[SUP]3[/SUP], Zhang X[SUP]4[/SUP], Fan B[SUP]5[/SUP], Wang C[SUP]6[/SUP], Zeng B[SUP]7[/SUP], Li Z[SUP]8[/SUP], Li X[SUP]9[/SUP], Li H[SUP]10[/SUP].
Author information
Abstract
PURPOSE:
To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia.
METHODS:
This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated.
RESULTS:
A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%.
CONCLUSION:
rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
Coronavirus; Pneumonia; Severe Acute Respiratory Syndrome; Tomography; X-Ray Computed
PMID:32229322PMCID:PMC7102545DOI:10.1016/j.ejrad.2020.108961
Free PMC Article