tetano
Editor, Senior Moderator
Eur J Pharmacol
. 2020 Oct 7;173620.
doi: 10.1016/j.ejphar.2020.173620. Online ahead of print.
Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review
Akram Yarmohammadi[SUP] 1 [/SUP], Mostafa Yarmohammadi[SUP] 1 [/SUP], Sajad Fakhri[SUP] 2 [/SUP], Haroon Khan[SUP] 3 [/SUP]
Affiliations
Abstract
As an emerging global health crisis, coronavirus disease 2019 (COVID-19) has been labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Amongst these dysregulated pathways inflammation seems to play a more critical role toward COVID-19 complications. In the present study, precise inflammatory pathways triggered by SARS-CoV-2, along with potential therapeutic candidates have been discussed.
Keywords: COVID-19; Cytokines; Inflammatory pathways; Interleukin; JAK/STAT; TLR.
. 2020 Oct 7;173620.
doi: 10.1016/j.ejphar.2020.173620. Online ahead of print.
Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review
Akram Yarmohammadi[SUP] 1 [/SUP], Mostafa Yarmohammadi[SUP] 1 [/SUP], Sajad Fakhri[SUP] 2 [/SUP], Haroon Khan[SUP] 3 [/SUP]
Affiliations
- PMID: 33038418
- DOI: 10.1016/j.ejphar.2020.173620
Abstract
As an emerging global health crisis, coronavirus disease 2019 (COVID-19) has been labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Amongst these dysregulated pathways inflammation seems to play a more critical role toward COVID-19 complications. In the present study, precise inflammatory pathways triggered by SARS-CoV-2, along with potential therapeutic candidates have been discussed.
Keywords: COVID-19; Cytokines; Inflammatory pathways; Interleukin; JAK/STAT; TLR.