tetano
Editor, Senior Moderator
Eur J Pediatr
. 2021 Aug 5.
doi: 10.1007/s00431-021-04221-w. Online ahead of print.
Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant
Patrick Morhart[SUP] 1 [/SUP], Christian Mardin[SUP] 2 [/SUP], Manfred Rauh[SUP] 1 [/SUP], Jörg Jüngert[SUP] 1 [/SUP], Johanna Hammersen[SUP] 1 [/SUP], Sven Kehl[SUP] 3 [/SUP], Wolfgang Schuh[SUP] 4 [/SUP], Sigrun Maier-Wohlfart[SUP] 1 [/SUP], Katharina Hermes[SUP] 5 [/SUP], Antje Neubert[SUP] 1 [/SUP], Michael Schneider[SUP] 3 [/SUP], Alexander Hein[SUP] 3 [/SUP], Joachim Woelfle[SUP] 1 [/SUP], Holm Schneider[SUP] 6 [/SUP]
Affiliations
Abstract
The risk and potential consequences of mother-to-child transmission of severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) during pregnancy are still a matter of debate. We studied the impact of SARS-CoV-2 infection on 56 complete households, including 27 newborns whose mothers were pregnant when exposed to the virus. Two PCR-confirmed perinatal SARS-CoV-2 transmissions with mild symptoms in affected neonates were recorded. In addition, we observed a severe eye malformation (unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy) associated with maternal SARS-CoV-2 infection in weeks 5 and 6 of embryonic development. This embryopathy could not be explained by other infectious agents, genetic factors, drug use, or maternal disease during pregnancy. Eight other women with a history of SARS-CoV-2 infection prior to gestational week 12, however, delivered healthy infants.Conclusion: The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women. Trial registration number: NCT04741412. Date of registration: November 18, 2020 What is Known: •Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases. What is New: •In a study of complete households with documented SARS-CoV-2 infection, including a cohort of pregnant women, we observed perinatal coronavirus transmission at a higher frequency than expected. •We also describe a newborn boy with an eye malformation reminiscent of rubella embryopathy but associated with early gestation SARS-CoV-2 infection of his mother. •A coronavirus-related embryopathy, reported here for the first time, is a finding that requires further investigation.
Keywords: Case report; Coronavirus; Embryopathy; Malformation; Materno-fetal transmission
. 2021 Aug 5.
doi: 10.1007/s00431-021-04221-w. Online ahead of print.
Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant
Patrick Morhart[SUP] 1 [/SUP], Christian Mardin[SUP] 2 [/SUP], Manfred Rauh[SUP] 1 [/SUP], Jörg Jüngert[SUP] 1 [/SUP], Johanna Hammersen[SUP] 1 [/SUP], Sven Kehl[SUP] 3 [/SUP], Wolfgang Schuh[SUP] 4 [/SUP], Sigrun Maier-Wohlfart[SUP] 1 [/SUP], Katharina Hermes[SUP] 5 [/SUP], Antje Neubert[SUP] 1 [/SUP], Michael Schneider[SUP] 3 [/SUP], Alexander Hein[SUP] 3 [/SUP], Joachim Woelfle[SUP] 1 [/SUP], Holm Schneider[SUP] 6 [/SUP]
Affiliations
- PMID: 34355278
- DOI: 10.1007/s00431-021-04221-w
Abstract
The risk and potential consequences of mother-to-child transmission of severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) during pregnancy are still a matter of debate. We studied the impact of SARS-CoV-2 infection on 56 complete households, including 27 newborns whose mothers were pregnant when exposed to the virus. Two PCR-confirmed perinatal SARS-CoV-2 transmissions with mild symptoms in affected neonates were recorded. In addition, we observed a severe eye malformation (unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy) associated with maternal SARS-CoV-2 infection in weeks 5 and 6 of embryonic development. This embryopathy could not be explained by other infectious agents, genetic factors, drug use, or maternal disease during pregnancy. Eight other women with a history of SARS-CoV-2 infection prior to gestational week 12, however, delivered healthy infants.Conclusion: The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women. Trial registration number: NCT04741412. Date of registration: November 18, 2020 What is Known: •Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases. What is New: •In a study of complete households with documented SARS-CoV-2 infection, including a cohort of pregnant women, we observed perinatal coronavirus transmission at a higher frequency than expected. •We also describe a newborn boy with an eye malformation reminiscent of rubella embryopathy but associated with early gestation SARS-CoV-2 infection of his mother. •A coronavirus-related embryopathy, reported here for the first time, is a finding that requires further investigation.
Keywords: Case report; Coronavirus; Embryopathy; Malformation; Materno-fetal transmission