tetano
Editor, Senior Moderator
Eur J Pediatr
. 2020 May 30;1-9.
doi: 10.1007/s00431-020-03699-0. Online ahead of print.
Children's Heart and COVID-19: Up-to-date Evidence in the Form of a Systematic Review
Giulia Sanna[SUP] 1 [/SUP], Gaia Serrau[SUP] 1 [/SUP], Pier Paolo Bassareo[SUP] 2 3 [/SUP], Paola Neroni[SUP] 1 [/SUP], Vassilios Fanos[SUP] 1 [/SUP], Maria Antonietta Marcialis[SUP] 1 [/SUP]
Affiliations
Abstract
The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and potentially life-threatening arrhythmias are the main aftermaths. A few studies showed that myocardial injury in adult patients is often linked with a fatal outcome. Conversely, scientific evidence in children is sparse, although several reports were published with the description of a cardiac involvement in COVID-19 paediatric patients. In these young subjects, a background of surgically treated congenital heart disease seems to be a predisposing factor.Conclusion: This systematic review is aimed at summarizing all COVID-19 cases with a cardiac involvement published in paediatric age and trying to explain the underlying mechanisms responsible for COVID-19-related myocardial damage.What is Known:• Coronaviruses proved to be able to jump from animals to humans.• The outbreak of COVID-19 started from China (Dec 2019) and became pandemic.What is New:• Even in childhood, COVID-19 is not without the risk of cardiac involvement.• Myocarditis, heart failure, and arrhythmias are among the possible manifestations.
Keywords: COVID-19; Cardiovascular; Coronavirus; Heart; Myocarditis; Severe respiratory distress syndrome.
. 2020 May 30;1-9.
doi: 10.1007/s00431-020-03699-0. Online ahead of print.
Children's Heart and COVID-19: Up-to-date Evidence in the Form of a Systematic Review
Giulia Sanna[SUP] 1 [/SUP], Gaia Serrau[SUP] 1 [/SUP], Pier Paolo Bassareo[SUP] 2 3 [/SUP], Paola Neroni[SUP] 1 [/SUP], Vassilios Fanos[SUP] 1 [/SUP], Maria Antonietta Marcialis[SUP] 1 [/SUP]
Affiliations
- PMID: 32474800
- PMCID: PMC7261213
- DOI: 10.1007/s00431-020-03699-0
Abstract
The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and potentially life-threatening arrhythmias are the main aftermaths. A few studies showed that myocardial injury in adult patients is often linked with a fatal outcome. Conversely, scientific evidence in children is sparse, although several reports were published with the description of a cardiac involvement in COVID-19 paediatric patients. In these young subjects, a background of surgically treated congenital heart disease seems to be a predisposing factor.Conclusion: This systematic review is aimed at summarizing all COVID-19 cases with a cardiac involvement published in paediatric age and trying to explain the underlying mechanisms responsible for COVID-19-related myocardial damage.What is Known:• Coronaviruses proved to be able to jump from animals to humans.• The outbreak of COVID-19 started from China (Dec 2019) and became pandemic.What is New:• Even in childhood, COVID-19 is not without the risk of cardiac involvement.• Myocarditis, heart failure, and arrhythmias are among the possible manifestations.
Keywords: COVID-19; Cardiovascular; Coronavirus; Heart; Myocarditis; Severe respiratory distress syndrome.