tetano
Editor, Senior Moderator
Eur J Med Res
. 2022 Jun 28;27(1):101.
doi: 10.1186/s40001-022-00729-5.
Initial viral cycle threshold values in patients with COVID-19 and their clinical significance
Salma AlBahrani[SUP] 1 2 [/SUP], Mohammed Alghamdi[SUP] 1 [/SUP], Nawaf Zakary[SUP] 1 [/SUP], Arulanantham Zechariah Jebakumar[SUP] 3 [/SUP], Samirah Jamaan AlZahrani[SUP] 1 [/SUP], Mohamed Hany ElGezery[SUP] 1 [/SUP], Khaled Omar Abdallah[SUP] 1 [/SUP], Jaffar A Al-Tawfiq[SUP] 4 5 6 [/SUP]
Affiliations
Abstract
Background: The connection between initial viral cycle threshold (Ct) values of the SARS-CoV-2 with symptoms and hospital course is not clearly studied.
Methods: This is a retrospective study of hospitalized COVID-19 patients from Jun 1st 2020 to March 30th, 2021 examining the relationship between initial viral cycle threshold (Ct) values of SARS-CoV-2 as obtained from nasopharyngeal samples. The clinical presentations and outcomes were analyzed in relation to the initial Ct values.
Results: The study included 202 hospitalized COVID-19 patients with a mean age (± SD) of 54.75 (± 15.93) and 123 (60.9%) males and 79 (39.1%) females. Of all the patients, the most frequent comorbidity was diabetes mellitus (95; 47%) and the most frequent symptoms were fever (148; 73.3%) and cough (141; 69.8%). There was no significant difference in relation to underlying conditions, clinical presentation, radiographic and laboratory data among those with low, medium and high Ct values. The mean Ct values showed no statistical change over the 10-month study period.
Conclusions: Initial SARS-CoV-2 Ct values did not show any association with clinical symptoms and did not predict the need for mechanical intubation or death.
Keywords: COVID-19; Coronavirus disease 2019; Cycle threshold; SARS-CoV-2; Viral load.
. 2022 Jun 28;27(1):101.
doi: 10.1186/s40001-022-00729-5.
Initial viral cycle threshold values in patients with COVID-19 and their clinical significance
Salma AlBahrani[SUP] 1 2 [/SUP], Mohammed Alghamdi[SUP] 1 [/SUP], Nawaf Zakary[SUP] 1 [/SUP], Arulanantham Zechariah Jebakumar[SUP] 3 [/SUP], Samirah Jamaan AlZahrani[SUP] 1 [/SUP], Mohamed Hany ElGezery[SUP] 1 [/SUP], Khaled Omar Abdallah[SUP] 1 [/SUP], Jaffar A Al-Tawfiq[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 35765070
- DOI: 10.1186/s40001-022-00729-5
Abstract
Background: The connection between initial viral cycle threshold (Ct) values of the SARS-CoV-2 with symptoms and hospital course is not clearly studied.
Methods: This is a retrospective study of hospitalized COVID-19 patients from Jun 1st 2020 to March 30th, 2021 examining the relationship between initial viral cycle threshold (Ct) values of SARS-CoV-2 as obtained from nasopharyngeal samples. The clinical presentations and outcomes were analyzed in relation to the initial Ct values.
Results: The study included 202 hospitalized COVID-19 patients with a mean age (± SD) of 54.75 (± 15.93) and 123 (60.9%) males and 79 (39.1%) females. Of all the patients, the most frequent comorbidity was diabetes mellitus (95; 47%) and the most frequent symptoms were fever (148; 73.3%) and cough (141; 69.8%). There was no significant difference in relation to underlying conditions, clinical presentation, radiographic and laboratory data among those with low, medium and high Ct values. The mean Ct values showed no statistical change over the 10-month study period.
Conclusions: Initial SARS-CoV-2 Ct values did not show any association with clinical symptoms and did not predict the need for mechanical intubation or death.
Keywords: COVID-19; Coronavirus disease 2019; Cycle threshold; SARS-CoV-2; Viral load.