tetano
Editor, Senior Moderator
Eur J Med Res
. 2025 Feb 24;30(1):131.
doi: 10.1186/s40001-025-02378-w. Guillain-Barré syndrome (GBS) after severe/critical COVID-19 or COVID-19 vaccination
Samira Bahrami[SUP] 1 [/SUP], Behnaz Ansari[SUP] 2 [/SUP], Leyla Norouzi-Barough[SUP] 1 [/SUP], Bahram Bagherpour[SUP] 1 [/SUP], Farzin Khorvash[SUP] 3 [/SUP], Kiana Shirani[SUP] 3 [/SUP], Saeed Abbasi[SUP] 4 [/SUP], Roya Sherkat[SUP] 5 [/SUP]
Affiliations
Background: The global COVID-19 pandemic was initiated by the appearance of the novel coronavirus SARS-CoV-2 in 2019, presenting a spectrum of clinical manifestations from asymptomatic cases to severe pneumonia and multi-organ dysfunction, with some cases leading to death induced by hyperinflammatory responses. Neurological manifestations have been reported in more than one-third of COVID-19 patients, particularly in severe instances. While vaccines are pivotal in combating infectious diseases and enhancing public health, reports have linked Guillain-Barré syndrome (GBS) to COVID-19 vaccination and infection. This study seeks to analyze four cases of GBS associated with COVID-19.
Methods: Clinical and demographic data were collected from all patients diagnosed with GBS from a biobank, including patients with severe COVID-19 and those with autoimmune conditions resulting from COVID-19 infection or vaccination, who were referred to Alzahra University Hospital in Isfahan, Iran, between October 2020 and December. 2023.
Results: Clinical and demographic data of affected patients are presented. This includes a unique family case involving a daughter who passed away due to GBS following AstraZeneca vaccination, her mother who succumbed to post-COVID-19 GBS, and her father who passed away from severe COVID-19 a year earlier.
Conclusions: These cases provide valuable insights into investigating potential genetic or epigenetic influences on GBS and hyperinflammation. Furthermore, the occurrence of GBS following exposure to COVID-19 and vaccination suggests shared pathways of autoimmunity induction by SARS-CoV-2 and vaccines.
Keywords: Autoimmunity; COVID-19 infection; COVID-19 vaccination; GBS.
. 2025 Feb 24;30(1):131.
doi: 10.1186/s40001-025-02378-w. Guillain-Barré syndrome (GBS) after severe/critical COVID-19 or COVID-19 vaccination
Samira Bahrami[SUP] 1 [/SUP], Behnaz Ansari[SUP] 2 [/SUP], Leyla Norouzi-Barough[SUP] 1 [/SUP], Bahram Bagherpour[SUP] 1 [/SUP], Farzin Khorvash[SUP] 3 [/SUP], Kiana Shirani[SUP] 3 [/SUP], Saeed Abbasi[SUP] 4 [/SUP], Roya Sherkat[SUP] 5 [/SUP]
Affiliations
- PMID: 39994747
- PMCID: PMC11849160
- DOI: 10.1186/s40001-025-02378-w
Background: The global COVID-19 pandemic was initiated by the appearance of the novel coronavirus SARS-CoV-2 in 2019, presenting a spectrum of clinical manifestations from asymptomatic cases to severe pneumonia and multi-organ dysfunction, with some cases leading to death induced by hyperinflammatory responses. Neurological manifestations have been reported in more than one-third of COVID-19 patients, particularly in severe instances. While vaccines are pivotal in combating infectious diseases and enhancing public health, reports have linked Guillain-Barré syndrome (GBS) to COVID-19 vaccination and infection. This study seeks to analyze four cases of GBS associated with COVID-19.
Methods: Clinical and demographic data were collected from all patients diagnosed with GBS from a biobank, including patients with severe COVID-19 and those with autoimmune conditions resulting from COVID-19 infection or vaccination, who were referred to Alzahra University Hospital in Isfahan, Iran, between October 2020 and December. 2023.
Results: Clinical and demographic data of affected patients are presented. This includes a unique family case involving a daughter who passed away due to GBS following AstraZeneca vaccination, her mother who succumbed to post-COVID-19 GBS, and her father who passed away from severe COVID-19 a year earlier.
Conclusions: These cases provide valuable insights into investigating potential genetic or epigenetic influences on GBS and hyperinflammation. Furthermore, the occurrence of GBS following exposure to COVID-19 and vaccination suggests shared pathways of autoimmunity induction by SARS-CoV-2 and vaccines.
Keywords: Autoimmunity; COVID-19 infection; COVID-19 vaccination; GBS.